Essentials of glycobiology
著者
書誌事項
Essentials of glycobiology
Cold Spring Harbor Laboratory Press, c1999
- : cloth
- : printed hardcover
- : pbk
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注記
Includes bibliographical references and index
内容説明・目次
- 巻冊次
-
: cloth ISBN 9780879695590
内容説明
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. They participate in activities as diverse as protein folding, leukocyte physiology and microbial pathogenesis. Genetic defects in their assembly are at the root of a growing list of human disease. This text presents a gateway to the understanding of glycans, and offers a textbook approach to describing their biogenesis and function. Written and edited by glycobiologists with experience in both teaching and research, this volume aims to be of interest to both students and established investigators in developmental biology, cell biology, neuroscience, immunology, and biochemistry, who need a complete yet concise introduction to this burgeoning field.
目次
- General principles
- biosynthesis, metabolism and function
- proteins that recognize glycans
- glycans in genetic disorders and disease
- methods and applications.
- 巻冊次
-
: printed hardcover ISBN 9780879695606
内容説明
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. They participate in activities as diverse as protein folding, leukocyte physiology and microbial pathogenesis. Genetic defects in their assembly are at the root of a growing list of human disease. This text presents a gateway to the understanding of glycans, and offers a textbook approach to describing their biogenesis and function. Written and edited by glycobiologists with experience in both teaching and research, this volume aims to be of interest to both students and established investigators in developmental biology, cell biology, neuroscience, immunology, and biochemistry, who need a complete yet concise introduction to this burgeoning field.
目次
- General principles
- biosynthesis, metabolism and function
- proteins that recognize glycans
- glycans in genetic disorders and disease
- methods and applications.
- 巻冊次
-
: pbk ISBN 9780879696818
内容説明
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. They participate in activities as diverse as protein folding, leukocyte physiology, and microbial pathogenesis. Genetic defects in their assembly are at the root of a growing list of human diseases. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans. Written and edited by glycobiologists with experience in both teaching and research, this volume should be useful for students and established investigators in developmental biology, cell biology, neuroscience, immunology, and biochemistry, who need a complete yet concise introduction to this burgeoning field.
目次
- General principles - historical background and overview
- saccharide structure and nomenclature
- evolution of glycan diversity
- protein-glycan Interactions
- exploring the biological roles of glycans
- biosynthesis, metabolism, and function - monosaccharide metabolism
- N-glycans
- O-glycans
- glycosphingolipids
- glycophospholipid anchors
- proteoglycans and glycosaminoglycans
- other classes of golgi-derived glycans
- nuclear and cytoplasmic glycosylation
- the O-GlcNAc modification
- sialic acids
- structures common to different types of glycans
- glycosyltransferases
- degradation and turnover of glycans
- glycosylation in "model" organisms
- glycobiology of plant cells
- bacterial polysaccharides
- proteins that recognize glycans - discovery and classification of animal lectins
- P-type lectins
- I-type lectins
- C-type lectins
- selectins
- S-type lectins (galectins)
- microbial glycan-binding proteins
- glycosaminoglycan-binding proteins
- plant lectins
- glycans in genetic disorders and disease - genetic disorders of glycosylation in cultured cells
- naturally occurring genetic disorders of glycosylation in animals
- determining glycan function using genetically modified mice
- glycosylation changes in ontogeny and cell activation
- glycosylation changes in cancer
- glycobiology of protozoal and helminthic parasites
- acquired glycosylation changes in human disease
- methods and applications - structural analysis and sequencing of glycans
- chemical and enzymatic synthesis of glycans
- natural and synthetic inhibitors of glycosylation
- glycobiology in biotechnology and medicine.
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