Transduction of BCR signals from the cell membrane to the nucleus
著者
書誌事項
Transduction of BCR signals from the cell membrane to the nucleus
（Current topics in microbiology and immunology, 245 . Signal transduction and the coordination of B lymphocyte development and function ; I）
Springer, c2000
大学図書館所蔵 件 / 全11件
-
該当する所蔵館はありません
- すべての絞り込み条件を解除する
注記
Includes bibliographical references
内容説明・目次
内容説明
Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.
目次
Signal Transduction via the B-cell Antigen Receptor: The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases.- The B-Cell Antigen Receptor: Formation of Signaling Complexes and the Function of Adaptor Proteins.- Intermediary Signaling Effectors Coupling the B-Cell Receptor to the Nucleus.- Involvement of the Lymphocyte Cytoskeleton in Antigen-Receptor Signaling.- Pax-5/BSAP: Regulator of Specific Gene Expression and Differentiation in B Lymphocytes.- Receptor Modulators of B-Cell Receptor Signalling - CD19/CD22.- Positive and Negative Signaling in B Lymphocytes.
「Nielsen BookData」 より