Apoptosis and cancer chemotherapy
著者
書誌事項
Apoptosis and cancer chemotherapy
(Cancer drug discovery and development, 5)
Humana Press, c1999
大学図書館所蔵 全10件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
The past few years have witnessed an astonishing international effort that established the role of some 20 new molecules in apoptosis and added activation or suppression of apoptosis to the accepted biological functions of a great many others already familiar in cancer biology. Some of these molecules are receptors, transducing cytokine-mediated signals; others appear to intensify or diminish the risk that a compro mised cell will fire its apoptosis effector mechanism. All are of interest as potential targets for tumor therapy, and some may prove to be control points influenced in the pathogenesis of cancer and other diseases as diverse as viral infection, neurodegenerative disorders, and stroke. Sometimes, in the midst of these developments, a kind of euphoria ap pears to have gripped the research community, with the expectation that apoptosis will afford explanations to many unsolved questions in cellu lar regulation. This book, in a series of thoughtful and provocative ar ticles--some from established leaders in the field, and others from younger scientists--seeks to redress the balance.
目次
Foreword, Andrew H. Wyllie. Does Apoptosis Contribute to Tumor Cell Sensitivity to Anticancer Agents?, J. Martin Brown and Bradly G. Wouters. p53, Apoptosis, and Chemosensitivity, Scott W. Lowe. The Role of p53 in Chemosensitivity, Wafik S. El-Deiry. Function of the p53 Gene Family: A Holistic Perspective, Sandra J. Campbell, Mary O'Neill, and Peter A. Hall. Mismatch Repair Deficiency, Apoptosis, and Drug Resistance, Robert Brown. Involvement of the c-Abl Tyrosine Kinase in Apoptotic Response to Anticancer Agents, Zhi-Min Yuan, Surender Kharbanda, Ralph Weichselbaum, and Donald Kufe. Bcl-2 Family Proteins: Relative Importance as Determinants of Chemoresistance in Cancer, John C. Reed. Bax, A Death Effector Molecule: Its Role in Development and Oncogenesis, Yi-Te Hsu and Richard. Youle. Bax, A Proapoptotic Protein Forming Channels in Mitochondria, Jean-Claude Martinou and Bruno Antonsson. Mechanism of Action of the Proapoptotic Gene Bak, Robin Brown. Killers or Clean-Up Crew: How Central are the Central Mechanisms of Apoptosis?, Douglas R. Green and Helen M. Beere. Role of CD95 (APO-1/Fas) System in Chemotherapy, Klaus-Michael Debatin. Insulin-Like Growth Factor-1 Receptor as a Target for Anticancer Therapy, Renato Baserga and Mariana Resnicoff. Drug Resistance and the Survival Niche: Survival Signals Combine to Suppress Drug-Induced Apoptosis in B-Lymphoma Cells, Sian T. Taylor and Caroline Dive. Chemotherapy, Tumor Microenvironment, and Apoptosis, Constantinos Koumenis, Nicholas Denko, and Amato J. Giaccia. Molecular Regulation and Therapeutic Implications of Cell Death in Prostate Cancer, Timothy J. McDonnell, Elizabeth M. Bruckheimer, Bjorn T. Gjertsen, Tsuyoshi Honda, and Nora M. Navone. Chemotherapy and Apoptosis in the Ovary: CancerTreatment Comes with a Price, Jonathan L. Tilly and Alan L. Johnson. Role of Bcl-2 Family Members in Homeostasis, in Toxicology in Normal Intestine, and for Prognosis of Colonic Carcinomas, D. Mark Pritchard. Apoptosis and BreastCancer, Nancy E. Davidson, Hillary A. Hahm, and Deborah K. Armstrong. Role of Apoptosis in Human Neuroblastomas, Garrett M. Brodeur and Valerie P. Castle. Response of Testicular Tumors to Chemotherapy: Relative Role of Drug-DNA Interactions and Apoptosis, Christine M. Chresta. Concluding Remarks: Has the Information Explosion on Apoptosis Affected Clinical Practice?, Joseph R. Bertino. Index.
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