Chemokines
Author(s)
Bibliographic Information
Chemokines
（Chemical immunology, v. 72）
Karger, c1999
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
Chemokines are a superfamily of small proteins which play a crucial role in immune and inflammatory reactions and in viral infection. They attract and activate leukocytes and regulate diverse cellular systems and organs ranging from blood vessels to the central nervous system. This book provides an overview of the main structural and functional features of chemokines. It presents recent studies which indicate that chemokines regulate the trafficking of dendritic cells and hence the activation of specific immunity and the subsequent orientation of immunity. Further contributions focus on the role of chemokines in the regulation of angiogenesis, and the interplay of HIV with chemokines and their receptors. Given the role of chemokines in diverse human diseases, their pharmacology is a prime target for research. In the last chapter, strategies to develop chemokine antagonists are discussed. Written by experienced investigators and summarizing current trends in this fast-moving field, this well-organized volume will be a useful reference for immunologists, virologists, oncologists, pharmacologists and neurobiologists.
Table of Contents
- Monocyte chemoattractant protein-1, L. Gu et al
- CCR2 - from cloning to the creation of knockout mice, I.F. Charo
- the role of CD26/DPP IV in chemokine processing, J. Van Damme et al
- chemokines and chemokine receptors in T-cell development, J.A. Hedrick and A. Zlotnick
- chemokines and chemokine receptors in the regulation of dendritic cell trafficking, P. Allavena et al
- the role of CXC chemokines in the regulation of angiogenesis, M.P. Keane and R.M. Strieter
- chemokines - function, regulation and alteration of inflammatory responses, N.W. Lukacs et al
- chemokines and human immunodeficiency virus, G. Poli
- inhibition of the expression and function of chemokine receptors on human CD4+ leukocytes by HIV-1 envelope protein gp 120, S.B. Su et al
- virally encoded chemokines and chemokine receptors - genetic embezzlement of host DNA, J.T. Stine et al
- strategies to interfere with the chemokine network in disease, T.N.C. Wells et al.
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