Percutaneous absorption : drugs--cosmetics--mechanisms--methodology

Author(s)

• Bronaugh, Robert L.
• Maibach, Howard I.

Bibliographic Information

Percutaneous absorption : drugs--cosmetics--mechanisms--methodology

edited by Robert L. Bronaugh, Howard I. Maibach

（Drugs and the pharmaceutical sciences, v. 97）

Dekker, c1999

3rd ed., rev. and expanded

Note

Includes bibliographical references and index

Description and Table of Contents

Description

Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research! Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details the applied biology of percutaneous penetration factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue And presents new chapters on mathematical models cutaneous metabolism prediction of percutaneous absorption in vitro absorption methodology dermal decontamination concentration of chemicals in skin transdermal drug delivery mechanisms of absorption safety evaluation of cosmetics absorption of drugs and cosmetic ingredients nail penetration Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines! An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.

Table of Contents

• Mechanisms of absorption: mathematical models in percutaneous absorption
• cutaneous metabolism during in vitro percutaneous absorption
• cutaneous metabolism of Xenobiotics
• occlusion does not uniformly enhance penetration in vivo
• regional variationin percutaneous absorption. Methodology: in vivo methods for percutaneous absorption measurements
• determination of percutaneous absorption by in vitro techniques
• will cutaneous levels of absorbed material be systemically absorbed
• dermaldecontamination and percutaneous absorption
• partioning of chemicals from water into powdered human stratum corneum (Callus) - a model study
• in vitro percutaneous absorption of model compounds glyphosate and malathion from fabric into and through humanskin
• vaginal absorption of prostaglandin E, in rhesus monkey
• human cadaver skin viability for in vitro percutaneous absorption - storage and detrimental effects of heat separation and freezing. Drug and cosmetic absorption: percutaneous penetration as amethod of delivery to skin and underlying tissues
• phonophoresis
• facilitated transdermal delivery by iontophoresis
• percutaneous penetration as it relates to the safety evaluation of cosmetic ingredients
• percutaneous absorption of fragrances
• hair dyeabsorption
• percutaneous absorption of alpha-hydroxy acids in human skin
• optimizing patch test delivery - a model
• permeation of N-nitrosamines through human skin
• nail penetration - focus on topical delivery of antifungal drugs for onchomycosistreatment
• topical dermatological vehicles - a holistic approach.

by "Nielsen BookData"

• NCID: BA43129884
• ISBN:
  • 0824719662
• LCCN: 99014994
• Country Code: us
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: New York
• Pages/Volumes: xxi, 955 p.
• Size: 24 cm
• Classification:
  • LCC : RM151
  • NLM : W1
  • NLM : WR 102
  • DC21 : 615/.6
• Subject Headings:
  • LCSH : Transdermal medication
  • LCSH : Skin absorption
  • LCSH : Skin -- Permeability
  • MESH : Skin Absorption
• Parent Bibliography ID:
  • BA03948165