Immune response and the eye
著者
書誌事項
Immune response and the eye
（Chemical immunology, v. 73）
Karger, c1999
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The primary purpose of this volume on immune responses and the eye is to describe, explain and speculate on what is known and understood about the consequences of the eye-immune system compromise, from the eye's standpoint. The research of the last two decades of the 20th century has witnessed remarkable advances in knowledge of the physiology of ocular immune privilege. The chapters in this book address this body of knowledge, looking at information gained concerning the mechanisms responsible for ocular inflammation secondary to viral, autoimmune and other immunopathogenic processes. Also, an understanding of immune responses in normal and inflamed eyes is used to explain the immunologic processes involved in the growth of ocular tumours and in the success and failure of transplants of cornea and retina.
目次
- Part 1 Introduction - all for saving the visual axis: the unusual nature of ocular immunity and inflammation
- immune mechanisms where the blood-ocular barrier meets the general circulation
- corneal endotheliitis and its related disorders
- teas as "Trojan horses" bearing ocular pathogens
- allergic conjunctival disorders
- the battle against cicatrizing ocular surface disorders
- molecular mimicry and autoimmune diseases of the eye
- antigen/pathogen clearance and connective tissue destruction
- concluding remarks. Part 2 Regional immunity and ocular immune privilege: principles of immune responses
- the immune reflex arc
- immune regulation, tolerance and the immune reflex arc
- concept of regional immunity
- understanding the mechanisms of immune privilege - influence of immune privilege on the immune reflex arc
- rationale for immune privilege in the eye. Part 3 Molecular and cellular aspects of allergic conjunctivits: animal models
- clinical studies
- mechanism of the allergic reaction
- timecourse of response
- T-cell-derived mediators and cytokines
- mast cells and mast cell mediators
- treatment of allergic conjunctivitis
- concluding remarks. Part 4 Anterior chamber-associated immune deviation: characteristics of ACAID
- is ACAID a Th2 immune response?
- role of antigen in the induction of ACAID
- role of the camerosplenic axis in ACAID
- role of fasL-induced apoptosis in ACAID
- diverging hyptheses on the induction and expression of ACAID
- what is the significance of ACAID?. Part 5 Ocular immunosuppressive microenvironment: introduction
- aqueous humour factors that suppress DTH
- immune responses modified by normal aqueous humour. Part 6 Mechanisms of intraocular inflammation: introduction
- nonspecific immune response
- antigen-specific immune response. Part 7 Immunopathogenesis of viral ocular infections: introduction
- viral infections involving the eye
- herpes simplex virus (HSV) ocular disease
- herpes simplex keratitis
- immunopathological mechanisms of HSK as defined in the mouse model
- antigen presentation in the HSV-1-infected cornea
- does HSV-1 trigger an autoimmune response in the cornea?. Part 8 Immune privilege, tumours and the eye: tumours as immune privileged sites and privileged tissues
- tumour antigens
- tumour escape mechanisms
- tumour escape following active immunization of cancer patients
- comparing immune privilege within the eye and tumours. Part 9 Immunopathogenic mechanisms in intraocular inflammation: introduction - what is uveitis?
- causes of IOI
- pathology of IOI
- how is IOI induced?
- experimental models
- evidence for systemic activation of T cells in uveitis
- mechanisms of tissue damage in IOI
- regulatory mechanisms in the eye and how these are disabled in IOI. Part 10 Immunobiology and immunopathology of corneal transplantation. Part 11 Retinal transplantation.
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