CiNii 図書 - Sphingolipid metabolism and cell signaling

Sphingolipids are found in all eukaryotic and in some prokaryotic organisms and provide structure for cell membranes, lipoproteins, and other biological materials as well as participate in the regulation of cell growth, differentiation, and diverse cell functions, including cell-cell communication, cell-substratum interactions, and intracellular signal transduction. This volume presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. Its companion Volume 312 will contain information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Sphingolipid Metabolism: Biosynthesis: R.C. Dickson, R.L. Lester, and M. Marek-Nagiec, Serine Palmitoyltransferase. M.M. Grilley and J. Y. Takemoto, Assay of the Saccharomyces cerevisiae Dihydrosphingosine C-4 Hydorxylase. B. Caligan, K. Peters. J. Ou, E. Wang, and A.H. Merrill, Jr., Ceramide Synthase. H. Schulze, C. Michel, and G. van Echten-Deckert, Dihydroceramide Desaturase. M.N. Nikolava-Karakashian, Assays for the Synthesis of Sphingomyelin (Ceramide Phosphocholine) and Ceramide Phosphoethanolamine. J.A. Shayman and A. Abe, Glucosylceramide Synthase: Assay and Properties. P. Marks, Y. Kamisaka, and R.E. Pagano, Methods for Studying Glucosylceramide Synthase. H. Sprong, G. van Meer, and P. van der Sluijs, UDP-Galactose: Ceramide Galactosyltransferase. S. Chatterjee, Assay of Lactosylceramide Synthase and Comments on Its Potential Role in Signal Transduction. G. Pohlentz, C. Kaes, and K. Sandhoff, In Vitro Assays for Enzymes of Ganglioside Synthesis. F.B. Jungalwala, P. Chatturvedi, D.S. Newburg, and M.R. Natowicz, Analyses of Sulfatides and Enzymes of Sulfatide Metabolism. J.A. Shayman and A. Abe, 1-O-Acyleceramide Synthase. T-C. Lee, N-Acetylation of Shingosine by Platelet-Activating Factor: Sphingosine Transacetylase. A.S. Fischl, Y. Liu, A. Browdy, and A.E. Cremesti, Inositolphosphoryl Ceramide Synthase from Yeast. D.V. Lynch, Enzymes of Shingolipid Metabolism in Plants. Turnover: S. Lansmann, O. Bartelsen, and K. Sandhoff, Purification and Characterization of Recombinant Human Acid Sphingomyelinase. B. Liu and Y.A. Hannun, Purification of Rat Brain Membrane Neutral Sphingomyelinase. B.Liu and Y.A. Hannun, Sphingolmyelinase Assay using Radiolabeled Substrates. A.G. Barbone, A.C. Jackson, D.M. Ritchie, and D.C. Argentieri, Robotic Assay of Sphingomyelinase Activity for High-Throughput Screening. D.F. Hassler, R. M. Laethem, and G.K. Smith, A High Through-put Sphingomyelinase Assay. R.T. Dobrowsky and V.G. Rao, Analysis of Sphingomyelin Hydrolosis in Caveolar Membranes. M.N. Nikolova-Karakashian and A.H. Merrill, Jr.,Ceramidases. T.Linke, S. Lansman, and K. Sandhoff, Purification of Acid Ceramidase from Human Placenta. S. Bajjalieh and R. Batchelor, Ceramide Kinase. A.Olivera, K.D. Barlow, and S. Spiegel, Assaying Sphingosine Kinase Activity. L.M. Obeid, Sphingosine 1-Phosphate Phosphatase. D.N. Brindley, J. Xu, R. Jasinska, and D.W. Waggoner, Analysis of Ceramide 1-Phosphate and Sphingosine 1-Phosphate Phosphatase Activities. P. Van Veldhover, Sphingosine 1-Phosphate Lyase. W. Bierfreund, T. Kolter, and K. Sandhoff, Sphingolipid Hydrolases and Activator Proteins. R-D. Duan and A. Nilsson, Sphingolipid Hydrolyzing Enzymes in the Gastrointestinal Tract. M. Basu, P. Kelly, M. Girzadas, Z. Li, and S. Basu, Properties of Animal Ceramide Glycanases. M. Ito, K. Kita, T. Kurita, N. Sueyoshi, and H. Izu, Enzymatic N-Deacylation of Shingolipids. Genetic Approaches: S. Ichikawa and Y. Hirabayashi, Genetic Approaches for Studies of Glycolipid Synthetic Enzymes. N.Chung and L.M. Obeid, Use of Yeast as a Model System for Studies of Sphingolipid Metabolism and Signaling. Inhibitors and Sphingolipid Biosynthesis: S.M. Mandala and G. H. Harris, Isolation and Characterization of Novel Inhibitors of Sphingolipid Synthesis: Austalifungin, Viridiofungins, Rustmicin, and Khafrefungin. R.T. Riley and R.D. Plattner, Fermentation, Partial Purification, and Use of Serine Palmitoyltransferase Inhibitors from Isaria (Cordyceps) sinclairii. F. Meredith, Isolation and Characterization of Fumonisins. J.A. Shayman, L. Lee, A. Abe, and L. Shu, Inhibitors of Glucosylceramide Synthase. Chemical and Enzymatic Syntheses: C. Cufman and D.C. Liotta, Synthesis of Sphingosine and Sphingoid Bases. K-H. Jung and R.K. Schmidt, Synthesis of Sphingosine, Radiolabeled Sphiongosine, 4-Methyl-cis-Sphingosine and 1-Amino Derivatives of Sphingosine via their Azido Derivatives. P.K. Koskinen and A.M.P. Koskinen, Total Synthesis of Sphingosine and its Analogs. A. Bielawska, Y.A. Hannun, and A. Szulc, Radiolabeled Sphingolipids, Part I. Radiolabeling in the Sphingolipid Backbone A. Bielawska and Y.A. Hannun, Radiolabeled Sphingolipids, Part II. Preparation of Radiolabeled Ceramides and Phospholsphingolipids. A. Bielawska, Z. Szulc, and Y.A. Hannun, Radiolabeled Sphingolipids, Part III. Synthesis of Key Precursors. A.S. Bushnev and D.C. Liotta, Practical Synthesis of N-Palmitoylsphingomyelin and N-Palmitoyldihydrosphingomyelin. M. Kiso and H. Ishida, Synthesis of Glycolipids, with a Focus on GM3, and Sulfatide Analogs. F. Knoll, T. Kolter, and K. Sandhoff, Sphingolipid Photoaffinity Labels. G. Schwarzmann, Synthesis and Characterization of Metabolically Stable Sphingolipids. J.Fanitni, Synthetic Soluble Analogs of Glycolipids for Studies of Virus Glycolipid Interactions. S. Sonnino, V. Chigorno, and G. Tettamanti, Preparation of Radioactive Gangliosides, 3H or 14C Isotopically Labeled at the Oligosaccharide or Ceramide Moieties. L. Riboni, P. Viani, and G. Tettamanti, Estimating Sphingolipid Metabolism and Trafficking in Cultured Cells Using Radiolabeled Compounds. M. Ito, S. Mitsutake, M. Tani, and K. Kita, Enzymatic Synthesis of 14C Ceramide, 14 C Glycosphingolipids, and W-Aminoceramide.

巻冊次: Pt. B ISBN 9780121822132

内容説明

This volume contains information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. Its companion Volume 311 presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Section I: Methods for Analyzing Sphingolipids [1]: Analysis of Sphingoid Bases and Sphingoid Base 1-Phosphates by High-Performance Liquid Chromatography [2]: Enzymatic Method for Measurement of Sphingosine 1-Phosphate [3]: Ceramide Mass Analysis by Normal-Phase High-Performance Liquid Chromatography [4]: Quantitative Determination of Ceramide Using Diglyceride Kinase [5]: Analysis of Sphingomyelin, Glucosylceramide, Ceramide, Sphingosine, and Sphingosine 1-Phosphate by Tandem Mass Spectrometry [6]: Analyses of Glycosphingollpids by High-Performance Liquid Chromatography [7]: Sphingolipid Extraction and Analysis by Thin-Layer Chromatography [8]: Extraction and Analysis of Multiple Sphingolipids from a Single Sample [9]: Purification of Sphingolipid Classes by Solid-Phase Extraction with Aminopropyl and Weak Cation Exchanger Cartridges [10]: Ganglioside Analysis by High-Performance Thin-Layer Chromatography [11]: Purification and Analysis of Gangliosides [12]: Thin-Layer Chromatography Blotting Using Polyvinylidene Difluoride Membrane (Far-Eastern Blotting) and Its Applications [13]: Thin-Layer Chromatography Immunostaining [14]: Monoclonal Anti-Glycosphingolipid Antibodies [15]: Immunolocalization of Gangliosides by Light Microscopy Using Anti-Ganglioside Antibodies [16]: Cloud-Point Extraction of Gangliosides using Nonionic Detergent C14EO6 [17]: Analyses of Glycosphingolipids Using Clam, Mercenaria mercenaria, Ceramide Glycanase [18]: Quantitative Analyses of Binding Affinity and Specificity for Glycolipid Receptors by Surface Plasmon Resonance [19]: Use of Circular Dichroism for Assigning Stereochemistry of Sphingosine and Other Long-Chain Bases [20]: Infrared Determination of Conformational Order and Phase Behavior in Ceramides and Stratum Corneum Models [21]: Use of Nuclear Magnetic Resonance Spectroscopy in Evaluation of Ganglioside Structure, Conformation, and Dynamics [22]: Fluorescence Quenching Assay of Sphingolipid/Phospholipid Phase Separation in Model Membranes Section II: Methods for Analyzing Aspects of Sphingolipid Metabolism in Intact Cells [23]: Synthesis of Fluorescent Substrates and Their Application to Study of Sphingolipid Metabolism in Vitro and in Intact Cells [24]: Selection of Mammalian Cell Mutants in Sphingolipid Biosynthesis [25]: Selection of Yeast Mutants in Sphingolipid Metabolism [26]: Fluorescence-Based Selection of Gene-Corrected Hematopoietic Stem and Progenitor Cells Based on Acid Sphingomyelinase Expression [27]: Mammalian Ganglioside Sialidases: Preparation and Activity Assays Section III: Sphingolipid-Protein Interactions and Cellular Targets [28]: Effects of Sphingosine and Other Sphingolipids on Protein Kinase C [29]: Kinetic Analysis of Sphingoid Base Inhibition of Yeast Phosphatidate Phosphatase [30]: Assays of Sphingosine-Dependent Kinase for 14-3-3 Protein [31]: Synthesis and Use of Caged Sphingolipids [32]: Binding of Sphingosine 1-Phosphate to Cell Surface Receptors [33]: Use of Short-Chain Ceramides [34]: Analysis of Ceramide-Activated Protein Phosphatases [35]: Use of Affinity Chromatography and TID-Ceramide Photoaffinity Labeling for Detection of Ceramide-Binding Proteins [36]: Lectin-Mediated Cell Adhesion to Immobilized Glycosphingolipids [37]: Analysis of Glycolipid-Dependent Cell Adhesion Based on Carbohydrate-Carbohydrate Interaction [38]: Analysis of Interactions between Glycosphingolipids and Microbial Toxins [39]: Oxidation of Aglycone of Glycosphingolipids: Serine and Ceramide Acid Precursors for Soluble Glycoconjugates [40]: Separation of Glycosphingolipid-Enriched Microdomains from Caveolar Membrane Characterized by Presence of Caveolin [41]: Reconstitution of Sphingolipid-Cholesterol Plasma Membrane Mlcrodomalns for Studies of Virus-Glycolipid Interactions [42]: Analysis of Ceramides Present in Glycosylphosphatidylinositol Anchored Proteins of Saccharomyces cerevisiae [43]: Preparation of Functionalized Lipid Tubules for Electron Crystallography of Macromolecules Section IV: Sphingolipid Transport and Trafficking [44]: Applications of BODIPY-Sphingolipid Analogs to Study Lipid Traffic and Metabolism in Cells [45]: Using Biotinylated Gangliosides to Study Their Distribution and Traffic in Cells by Immunoelectron Microscopy [46]: Assays for Transmembrane Movement of Sphingolipids Section V: Other Methods [47]: Compilation of Methods Published in Previous Volumes of Methods in Enzymology Author Index Subject Index

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Sphingolipid metabolism and cell signaling

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