Prion biology and diseases
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Bibliographic Information
Prion biology and diseases
（Cold Spring Harbor monograph series, 38）
Cold Spring Harbor Laboratory Press, c1999
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Includes bibliographic references and index
Description and Table of Contents
Description
After initial skepticism, it is now generally accepted that prions exist, that they differ from all other pathogens, and that they are infectious in several species. Prions are implicated in spongiform encephalopathies such as kuru, Creutzfeldt-Jakob disease and fatal familial insomnia in humans, scrapie in sheep and a bovine encephalopathy that may be transmissible to humans. Driven by prions' novelty and by concern about their public health effects, awareness of these pathogens has grown enormously, prompting an immense amount of sometimes conflicting research. This text aims to present an authoritative account of prion biology and disease, offering scientists, educators and students a source of reliable reference material.
Table of Contents
- Part 1 Prion biology: an introduction to prion biology and diseases
- development of the prion concept
- bioassays of prions
- transmission and replication of prions
- structural studies of prion proteins. Part 2 Fungal prions: prions of fungi - [URE3], [PSI], and [Het-s] discovered as heritable traits. Part 3 Transgenetics and cell biology of prions: knockouts, transgenics, and transplants in prion research
- transgenetic investigation of species barrier and prion strains
- cell biology of prions. Part 4 Prion diseases in animals: scrapie, chronic wasting disease, and transmissible mink encephalopathy
- bovine spongiform encephalopathy and related diseases. Part 5 Human prion diseases: infectious and sporadic prion diseases
- inherited prion diseases
- neuropathology of prion diseases. Part 6 Methodology and future studies: some strategies and methods for the study of prions
- antibodies as tools to probe protein (PrP) biology
- biosafety issues in prion diseases.
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