Prostaglandins, leukotrienes, and other eicosanoids : from biogenesis to clinical applications
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書誌事項
Prostaglandins, leukotrienes, and other eicosanoids : from biogenesis to clinical applications
Wiley-VCH, c1999
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Polyunsaturated fatty acids are essential for human cell metabolism. As precursors of a very large and extremely versatile family of signaling compounds they play a key role in intercellular communication. Eicosanoids constitute one of the most abundant and prominent subfamilies of these fatty acid derivatives which are formed primarily along oxidative pathways. Prostaglandins, leukotrienes, and related eicosanoids have a modulatory function in mammalian cells and are responsible for tissue responses such as inflammation or wound repair. Increasing activity in eicosanoid research sheds new light on today's most common diseases including atherosclerosis, cancer, Alzheimer's, allergies, and rheumatic diseases. The recent advances already have far-reaching implications in medicine. This detailed account, written by experts, covers the developments in recent eicosanoid research. The topics span eicosanoid biogenesis, new aspects of their pathophysiology, for example their influence on the cardiovascular system, as well as the clinical application of synthetic eicosanoids and their antagonists.
Researchers and students working in biochemistry or in pharmaceutical, physiological, medicinal and neurochemistry should find this an informative introduction to one of the most rapidly developing fields in cell biology.
目次
- Arachidonic acids and companions - an abundant source of biological signals
- the generation of free arachidonic acid
- cyclooxygenases
- prostaglandin synthases/lipoxygenases
- oxygenation of arachidonic acid by cytochromes P450
- renal eicosanoids
- the role of eicosanoids in reproduction
- the role of eicosanoids in inflammation and allergy
- prostaglandins and the cardiovascular system
- eicosanoids and cancer
- synthetic eicosanoids and eicosanoid antagonists - development and clinical application.
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