Vitamin E-bonded membrane : a further step in dialysis optimization
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Bibliographic Information
Vitamin E-bonded membrane : a further step in dialysis optimization
（Contributions to nephrology, vol. 127）
Karger, c1999
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Vitamin E bonded membrane
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Includes bibliographical references and indexes
Description and Table of Contents
Description
In recent years, major concerns have been expressed about long-term derangements in hemodialysis patients and possible clinically relevant blood-membrane interactions. Preliminary studies employing biocompatible membranes and antioxidant agents such as vitamin E have demonstrated significant improvements in patient organ function and hemopoietic capacity with increased hematocrit and quality of life. Using a new technology, vitamin E has now been successfully bound to the inner surface of a hollow-fiber membrane, so that the patient's blood is flowing in contact with a layer of antioxidant agent covering the inner surface of the membrane in the hemodialyzer. The opening chapters of this publication give an overview on oxidant stress and the role of vitamin E as antioxidant agent and elaborate on technical aspects, hydraulics and permeability characteristics of the membrane in question. The main part is dedicated to the hemocompatibility of the membrane, its effect on erythrocyte morphology and survival and the impact on white cell and platelet function. The metabolic effects and the antioxidant impact of the vitamin E-coated membrane are presented in the last part of the book. Intended as a reference tool for professionals, students and fellows involved in the care of end-stage renal disease patients, it is also hoped that this book serves as a starting point for further speculations and research in the field.
Table of Contents
- Pathophysiology of the oxidative stress and its implication in uremia and dialysis
- vitamin E as an antioxidant agent
- chronic haemolysis and erythrocyte survival in haemodialysis patients treated with vitamin E-modified dialysis filters
- development of vitamin E-modified membrane
- evaluation of excebrane by infrared imaging
- hydraulic and flow dynamic characteristics of vitamin E-bonded dialyzers
- urea clearance and ionic dialysance of excebrane haemodialyzers
- effect of several cellulosic dialytic membranes on hyperhomocysteinemia and on the oxidative stress in dialysis patients - any role for curay and vitamin E?
- hollow-fiber dialyzer employing vitamin E-bonded membrane - a morphological analysis
- does vitamin E bound on dialysis membrane improve the LDL susceptibility to oxidation? lessons from an in vitro model
- effect of vitamin E conjugated to dialysis membranes on immunohaematopoietic cell growth and signalling
- effects of vitamin E-modified dialyzer (Excebrane) on beta-2-microglobulin structure and removal
- lipid peroxidation, leukocyte function and apoptosis in haemodialysis patients treated with vitamin E-modified filters
- morphologic evaluation of red blood cells using vitamin E-modified dialysis filters
- Excebrane - haemocompatibility studies by the intradialytic monitoring of oxygen saturation
- effect of a new vitamin E-coated membrane on glycoxidation during haemodialysis
- in vivo evaluation of biocompatibility of a new dialyzer employing the vitamin E-modified cellulose membrane "Excebrane E" - study of mechanisms involved in mononuclear cell activation
- increased red blood cell survival reduces the need of erythropoietin in haemodialyzed patients treated with exogenous glutathione and vitamin E-modified membrane
- a chemiluminescence assay for the detection of reactive oxygen species produced by human neutrophils - in vitro comparison of vitamin E-modified multilayer haemodialysis filter with a polysulfone dialyzer
- immunological biocompatibility characterization of a vitamin E-bonded membrane
- long-term effects of vitamin E-bonded dialysis membrane on mononuclear cell activation, malondialdehyde generation and endothelial function in ESRD patients
- effect of vitamin E-modified regenerative cellulose membrane on neutrophil superoxide anion radical production and lipid peroxidation
- suppressive effects of vitamin E-coated dialysis membrane on haemodialysis-induced neutrophil activation.
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