Genetics and psychiatric disorders
著者
書誌事項
Genetics and psychiatric disorders
（Wenner-Gren international series, v. 69）
Pergamon, 1998
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Recentlt, there has been much research into, and subsequent advances in our understanding of, the genetic causes of psychiatric illness. Most neuropsychiatric diseases have a multifactorial background - both genetic and environmental factors are important for the development of the disease. The advantages of understanding the inherited component of a psychiatric disease are obviously great, and will eventually lead to more effective treatments. HoweveThe chapters in this volume are specifically concerned with the latest advances in finding biological and genetic markers for psychiatric disorders. An emphasis is placed on common diseases such as schizophrenia and bipolar disorders. r, f or instance, monogenetic inherited diseases with psychiatric symptoms which can serve as models for the inheritance of psychiatric disorders are also discussed.
目次
Human genetic diversity and neuropsychiatric disorders (K.K. Kidd). Section I. Methods and Models. Paralogous genes and nervous systems (L-G. Lundin, D. Larhammar). The candidate gene approach in psychiatric disorders: the example of tyrosine hydroxylase (J. Mallet, R. Meloni). Molecular analysis of genomes and genes (U. Landegren). The molecular basis for acute intermittent prophyria, an inherited disease associated with neurological and psychiatric disturbances (P.M. Shoolingin-Jordan, S.P. Wood). Section II. Candidate Genes in Psychiatric Disorders. Genetics of the 5-HT transporter: allelic variation in functional expression affects anxiety- and depression-related personality traits and suceptibility to affective disorders (P.K. Lesch, A. Heils, D. Bengel). Genetic variation in human dopamine receptors (M.M. Nothen, S. Cichon, P. Propping). Section III. Psychiatric Diseases and Linkage Studies. Bipolar disorder: molecular linkage studies (W.H. Berrettini). Genomic screening in manic-depressive disorder (G.R. Verheyen, C. Van Broeckhoven). Genomic trinucleotide screening in neuropsychiatric disorders (M. Schalling, K. Lindblad, C.E. Burgess, C. Zander, P-O. Nylander, C. Engstrom, R. Adolfsson). Unstable DNA in psychiatric disorders (J.B. Vincent, A. Petronis, J.L. Kennedy). The case for an X-Y homologous locus in the evolution of language and the origins of psychosis (T.J. Crow). Current status of the genetics of narcolepsy (C.L. Barr, C.M. Shapiro). Section IV. Dynamic Expansion Related to Psychiatric Disorders. Genetic anticipation and brain genes (M.G. McInnis). The fragile X syndrome (P.J. Willems). Section V. Late Incoming News. The gene map of psychiatric disorder (J. Wahlstrom). Polyglutamine expansions and neurodegenerative diseases (F. Sandou, D. Devys, Y. Trottier, G. Imbert, M-E. Stoeckel, A. Brice, J-L. Mandel). Section VI. Clock Genes. A molecular mechanism for the control of circadian behavioral rhythms in drosophila (M.W. Young). Biological rhythms and psychiatric disease: focus on melatonin-related genes (D.C. Klein, S.L. Coon, K. Mazuruk, M. Bernard, P.H. Rosenboom, I.R. Rodriquez). Section VII. Future Research. Genomic screening in schizophrenia (H.W. Moises). Future directions in genetics and psychiatric disorders (P.M. Conneally).
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