Solid-phase organic synthesis
著者
書誌事項
Solid-phase organic synthesis
Wiley-Interscience, c2000
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Solid-Phase Organic Synthesis Edited by Kevin Burgess, Texas A & M University Efficient, high-throughput chemistry is now the focus of many research laboratories. Solid-phase organic syntheses are central to many of these combinatorial and parallel screening methodologies. Consequently, they have been a major scientific theme of the 1990s and promise to remain prominent for the first part of the new millennium. Indeed, a bewildering number of papers have entered the literature on this topic; some report minor modifications enabling transformation of solution-phase methods to a solid support, while others report major innovations. Solid-Phase Organic Synthesis collects, highlights, and critiques some of the key developments in the field. Leading practitioners explain different perspectives on diverse aspects of the area. Specific topics covered include:
* Syntheses of guanidines
* Palladium-catalyzed C-C bond forming reactions
* S_nAr reactions for the formation of heterocycles
* Sequence-specific arylalkyne oligomers
* Resin-supported capture agents and other reagents
* Synthesis on pins
* Monitoring of supported reactions using IR
* Solid-phase syntheses of natural product derivatives
Of related interest . Combinatorial Chemistry and Molecular Diversity in Drug Discovery Eric M. Gordon and James F. Kerwin 1998 (0-471-15518-7) 544 pp. Combinatorial Chemistry Synthesis and Application Stephen R. Wilson and Anthony W. Czarnik 1997 (0-471-12687-X) 288 pp.
目次
Solid Phase Syntheses of Guanidines (K. Burgess & J. Chen).
Palladium-catalyzed Carbon-carbon Bond Formation on Solid Supports (M. Todd & C. Abell).
Benzofused Heterocycles via Solid-phase S_NAr Reactions (M. Schwarz & M. Gallop).
Solid-phase Synthesis of Sequence-specific Phenylacetylene Oligomers (J. Moore, et al.).
Polymer-assisted Solution Phase Methods for Chemical Library Synthesis (D. Flynn, et al.).
Solid-phase Organic Synthesis on Radiation-grafted Polymer Surfaces: Application of SynPhase(TM) Crowns to Multiple Parallel Syntheses (I. James, et al.).
Vibrational Spectroscopy for Optimization of Solid-phase Organic Syntheses (B. Yan).
Recent Advances in Solid-phase Synthesis of Natural Products (L. Wilson).
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