Solid-phase organic synthesis

著者

    • Burgess, Kevin L.

書誌事項

Solid-phase organic synthesis

edited by Kevin Burgess

Wiley-Interscience, c2000

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Solid-Phase Organic Synthesis Edited by Kevin Burgess, Texas A & M University Efficient, high-throughput chemistry is now the focus of many research laboratories. Solid-phase organic syntheses are central to many of these combinatorial and parallel screening methodologies. Consequently, they have been a major scientific theme of the 1990s and promise to remain prominent for the first part of the new millennium. Indeed, a bewildering number of papers have entered the literature on this topic; some report minor modifications enabling transformation of solution-phase methods to a solid support, while others report major innovations. Solid-Phase Organic Synthesis collects, highlights, and critiques some of the key developments in the field. Leading practitioners explain different perspectives on diverse aspects of the area. Specific topics covered include: * Syntheses of guanidines * Palladium-catalyzed C-C bond forming reactions * S_nAr reactions for the formation of heterocycles * Sequence-specific arylalkyne oligomers * Resin-supported capture agents and other reagents * Synthesis on pins * Monitoring of supported reactions using IR * Solid-phase syntheses of natural product derivatives Of related interest . Combinatorial Chemistry and Molecular Diversity in Drug Discovery Eric M. Gordon and James F. Kerwin 1998 (0-471-15518-7) 544 pp. Combinatorial Chemistry Synthesis and Application Stephen R. Wilson and Anthony W. Czarnik 1997 (0-471-12687-X) 288 pp.

目次

Solid Phase Syntheses of Guanidines (K. Burgess & J. Chen). Palladium-catalyzed Carbon-carbon Bond Formation on Solid Supports (M. Todd & C. Abell). Benzofused Heterocycles via Solid-phase S_NAr Reactions (M. Schwarz & M. Gallop). Solid-phase Synthesis of Sequence-specific Phenylacetylene Oligomers (J. Moore, et al.). Polymer-assisted Solution Phase Methods for Chemical Library Synthesis (D. Flynn, et al.). Solid-phase Organic Synthesis on Radiation-grafted Polymer Surfaces: Application of SynPhase(TM) Crowns to Multiple Parallel Syntheses (I. James, et al.). Vibrational Spectroscopy for Optimization of Solid-phase Organic Syntheses (B. Yan). Recent Advances in Solid-phase Synthesis of Natural Products (L. Wilson).

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