Current progress in the understanding of secondary brain damage from trauma and ischemia
著者
書誌事項
Current progress in the understanding of secondary brain damage from trauma and ischemia
(Acta neurochirurgica, Supplement ; 73)
Springer, c1999
大学図書館所蔵 全1件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Information is provided from the basic and clinical sciences on the mechanisms damaging the brain from trauma or ischemia. New aspects involve the endoplasmic reticulum, mitochondrial failure, pathobiology of axonal injury, molecular signals activating glial elements, or the emerging therapeutical role of neurotrophins. Experimental issues involve a better analysis of the ischemic penumbra, the salvagable tissue. Therapeutic contributions reach from the environmental influence to gene expression, including neuroprotection, such as hibernation - mother nature's experiment - or hypothermia which is reported to induce cell swelling. Treatment issues deal also with thrombolysis and combination therapies, or with the clearance of adverse blood components - LDL/fibrinogen - by a novel procedure using heparin. Other highlights are discussing the specificities of pediatric vs. adult brain trauma, or the evolving role of the Apolipoprotein-E e4 gene in severe head injury. An update is also provided on an online assessment of the patient management during the pre- and early hospital phase in Southern Bavaria.
The empirical observation of neuroworsening is analyzed in further details, whether this is a specificity autonomously driving the posttraumatic course. Finally, the unsolved question why drug trials in severe head injury have failed so far in view of the promising evidence from the laboratory is subjected to an expert analysis.
目次
Molecular and Cellular Mechanisms Disturbance of Endoplasmic Reticulum Functions - A Key Mechanism Underlying Cell Damage? * Role and Mechanisms of Secondary Mitochondrial Failure * Initiating Mechanisms Involved in the Pathobiology of Traumatically Induced Axonal Injury and Interventions Targeted at Blunting their Progression * Molecular Signals for Glial Activation: Pro- and Anti-Inflammatory Cytokines in the Injured Brain * Mechanical and Excitotoxic Lesion of Motoneurons: Effects of Neurotrophins and Ciliary Neurotrophic Factor on Survival and Regeneration News from Cerebral Ischemia Modelling of the Ischemic Penumbra * The Acute Ischemic Penumbra: Topography, Life Span, and Therapeutic Response * Environmental Influence on Gene Expression and Recovery from Cerebral Ischemia * Neuroprotective Strategies in Nature - Novel Clues for the Treatment of Stroke and Trauma * Glial Cell Swelling - Effect of Hypothermia * The Clot Thickens - Thrombolysis and Combination Therapies * Assessment of brain tissue viability under clinical Circumstances * Heparin-Mediated Extracorporeal LDL/Fibrinogen Precipitation - H.E.L.P. - In Coronary and Cerebral Ischemia Remaining Problems in Severe Head Injury Pediatric Head Injury: What is Unique and Different? * Apolipoprotein E and the Response of the Brain to Injury * System Analysis of Patient Management During the Pre- and Early Clinical Phase in Severe Head Injury * The Frequency, Antecedent Events, and Causal Relationships of Neurologic Worsening Following Severe Head Injury * Neuroprotective Effects of Riluzole in Neurotrauma Models: A Review * Challenges in Translating the Efficacy of Neuroprotective Agents in Experimental Models Into Knowledge of Clinical Benefits in Head Injured Patients
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