CiNii 図書 - Biochemistry of signal transduction and regulation

Intracellular signal transduction, regulation of cell activities, and tumor formation - how do they work? This question is of central importance in biochemical research. The 1990s have seen great progress in the understanding of the molecular basis of biological signal transduction, and many facts are known by every medicinal chemist, biochemist, and biologist. This book relates the observed biological phenomena to the underlying biological processes. The topics range from function, structure and integral construction of signalling pathways, including a detailed description of the various types of carriers, to regulation of the cell cycle, and the role of ion channels in signal transduction. Special emphasis is placed on oncogenesis and tumour suppressants. A comprehensive bibliography including review articles provides access to the primary literature on the subject.

Regulation of gene expression
regulation of enzyme activities
function and structure of signalling pathways
signal transduction through nuclear receptors
G-protein-coupled signal transduction pathways
intracellular signalling agents: "Second messenger"
ser/thr-specific protein kinases and protein phosphatases
signal transduction through transmembrane receptors with tyrosine-specific protein kinase activity
signal transduction through ras-proteins
intracellular signal transduction - protein kinase cascade of MAP-kinase pathways
membrane receptors with associated tyrosine-kinase activity
transmembrane receptors with intrinsic ser/thr-kinase activity and signal transduction in the "Two-Component Pathway"
integral construction, networks, and specifity of signalling pathways
regulation of the cell cycle
malfunction of signalling pathways and tumor formation - oncogenes and tumor suppressants
apoptosis
ion channels and signal transduction.

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Biochemistry of signal transduction and regulation

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