Retroviral oncogens
Author(s)
Bibliographic Information
Retroviral oncogens
（Progress in gene expression, Oncogenes as transcriptional regulators ; vol. 1）
Birkhauser, 1997
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Description and Table of Contents
Description
The study of the molecular events leading to cellular transformation and cancer has progressed significantly in the last decade, and it has become apparent that many genes subject to modification in cancer are, in fact, transcription factors that govern the execution of the genetic programme of the cell. Transcription factors can behave either as oncogenes or as tumour suppressor genes. To date only a limited number of transcription factors have been associated with cancer. This volume deals with several transcription factor families that were first identified in oncogenic retroviruses. Each chapter contains a description of the structure of the transcription factors, the nature of target genes, the regulation of their activities, and an explaination of how they can deregulate cell growth and differentiation. This text should be suitable for the specialist scientist and the advanced student
Table of Contents
- Oncogenes encoding transcription factors, J. Ghysdael and M. Yaniv
- Myc structure and formation, G.C. Prendergast
- the ETS family of transcriptional regulators, J. Ghysdael and A. Boureux
- myb proto-oncogene product as a transcriptional regulator, S Ishii
- the v-erbA oncogene, A. Rascle, O Gandrillon, G. Cabello, and J. Samarut
- rel proteins and their inhibitors: a balancing act, M.L. Mackichan and A. Israel
- structure/function and oncogenic conversion of Fos and Jun, A.J. Bannister and T. Kouzarides.
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