Free radical toxicology
Author(s)
Bibliographic Information
Free radical toxicology
(Target organ toxicology series)
Taylor & Francis, c1997
- alk. paper
Available at 3 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes bibliographical references and index
Description and Table of Contents
Description
Provides insight into the involvement of free radicals in the pathogenesis of chemical-induced toxic tissue injury. The text addresses the fundamentals of free radical chemistry and the theoretical basis for electron transfer reaction leading to free radical generation. It describes the various subcellular sources of free radicals, the biological reactivity with lipid, protein and nucleic acids, and the physiochemical determinants of free radical-induced cell injury and the various antioxidant defence systems. The book focuses on target organ toxicity, and the concluding section offers an overview of the evidence implicating free radicals in the aetiology of various chemical toxicities, challenging the possibility of misguided use of biomarkers for oxidative damage.
Table of Contents
1. The Chemical Reactivity of Radicals 2. Physical Chemical Determinants of Xenobiotic Free-Radical Generation - The Marcus Theory of Electron Transfer 3. Subcellular Sites of Xenobiotic-induced Free Radical Generation 4. Formation and Biological Reactivity of Lipid Peroxidation Products 5. Free-Radical-Mediated Modification of Proteins 6. Free-Radical-Mediated DNA Oxidation 7. Physiochemical Determinants of Free-radical Cytotoxicity 8. Free-Radical Defence and Repair Mechanisms 9. Free-Radical-Mediated Liver Injury 10. Free-Radical-Mediated Kidney Injury 11. Free-Radical-Mediated Chemical Cardiomyopathies 12. Free-Radical-Mediated Toxic Injury to the Nervous System 13. Free-Radical-Mediated Hematopoietic Toxicity by Drugs, Environmental Pollutants and Ionising Radiation 14. Selected Examples of Free Radicals Mediated Lung Injury 15. Activation of the Inflammatory Response by Asbestos and Silicate Mineral Dusts 16. Free-Radical-Mediated Alterations of Gene Expression by Xenobiotics 17. Free-Radical-Induced Changes in Cell Signal Transduction 18. Free-Radical Oxygen-Induced Changes in Chemical Carcinogenesis 19. Markers of Free-Radical-Mediated Tissue Injury: Tales of Caution and Woe
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