Cell cycle regulators and chromosomal translocation
著者
書誌事項
Cell cycle regulators and chromosomal translocation
（Progress in gene expression, Oncogenes as transcriptional regulators ; vol. 2）
Birkhauser, 1997
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内容説明・目次
内容説明
The study of molecular events leading to cellular transformation and cancer has progressed considerably during the 1990s. It has become apparent that many genes subject to modification in cancer are, in fact, transcription factors that govern the execution of the genetic programme of the cell. Transcription factors can behave either as oncogenes or as tumor supressor genes. To date only a very limited number of transcription factors have been associated with cancer. This volume gives molecular information on several oncogenes, tumor suppressor genes or chromosomal translocations. Each chapter contains a description of the structure of such transcription factors, the nature of target genes, the regulation of their activities and an explaination of how they can deregulate cell growth and differentiation. This book should be suitable for the specialist scientist and the advanced student
目次
- E2Fs and the retinoblastoma protein family, C. Sardet, L. LeCam, E. Fabbrizio and M. Vidal
- signalling to the C-terminus of p53, C. Cain, S-Y Sheih, and C. Prives
- chromosome translocations generating chimeric transcription factors, unique genetic events with pleiotropic cellular consequences, Y. Labelle and P. Delattre
- the runt domain transcription factor, PEBP2/CBF and its involvement in human leukemia, Y. Ito and S-C. Bae
- EBNA2 - a viral transcription factor essential for the immortalization of human B Lymphocytes by the Epstein-Barr Virus (EBV), L Waltzer, F. Meggetto, A. Sergeant, and E. Manet.
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