Bioinformatics methods and protocols

Author(s)

    • Misener, Stephen
    • Krawetz, Stephen A.

Bibliographic Information

Bioinformatics methods and protocols

edited by Stephen Misener and Stephen A. Krawetz

(Methods in molecular biology / John M. Walker, series editor, v. 132)

Humana Press, c2000

Available at  / 20 libraries

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Note

Includes bibliographical references and index

Description and Table of Contents

Description

Computers have become an essential component of modern biology. They help to manage the vast and increasing amount of biological data and continue to play an integral role in the discovery of new biological relationships. This in silico approach to biology has helped to reshape the modern biological sciences. With the biological revolution now among us, it is imperative that each scientist develop and hone today's bioinformatics skills, if only at a rudimentary level. Bioinformatics Methods and Protocols was conceived as part of the Methods in Molecular Biology series to meet this challenge and to provide the experienced user with useful tips and an up-to-date overview of current developments. It builds upon the foundation that was provided in the two-volume set published in 1994 entitled Computer Analysis of Sequence Data. We divided Bioinformatics Methods and Protocols into five parts, including a thorough survey of the basic sequence analysis software packages that are available at most institutions, as well as the design and implemen- tion of an essential introductory Bioinformatics course. In addition, we included sections describing specialized noncommercial software, databases, and other resources available as part of the World Wide Web and a stimul- ing discussion of some of the computational challenges biologists now face and likely future solutions.

Table of Contents

Part 1. Sequence Analysis Packages GCG: The Wisconsin Package of Sequence Analysis Programs David D. Womble Web-Based Interfaces for the GCG Sequence Analysis Programs David D. Womble Omiga: A PC-Based Sequence Analysis Tool Jeffrey A. Kramer MacVector: Integrated Sequence Analysis for the Macintosh Promila A. Rastogi DNASTAR's Lasergene Sequence Analysis Software Timothy G. Burland PepTool (TM) and GeneTool (TM): Platform-Independent Tools for Biological Sequence Analysis David S. Wishart, Paul Stothard, and Gary H. Van Domselaar The Staden Package, 1998 Rodger Staden, Kathryn F. Beal, and James K. Bonfield Building a Multiuser Sequence Analysis Facility Using Freeware Brian Fristensky Part 2. Molecular Biology Software Free Software in Molecular Biology for Macintosh and MS Windows Computers Appendix: Software Listings Don Gilbert Flexible Sequence Similarity Searching with the FASTA3 Program Package William R. Pearson The Use of CLUSTAL W and CLUSTAL X for Multiple Sequence Alignment Ashok Aiyar Phylogenetic Analysis Using PHYLIP Jacques D. Retief Annotating Sequence Data Using Genotator Nomi L. Harris Low Cost Gel Analysis Jeffry A. Reidler Part 3. Web-Based Resources Computer Resources for the Clinical and Molecular Geneticist Yuval Yaron and Avi Orr-Urtreger The NCBI: Publicly Available Tools and Resources on the Web Jack P. Jenuth Resources at EBI Patricia Rodriguez-Tome Computer-Assisted Analysis of Transcription Control Regions: MatInspector and Other Programs Thomas Werner Computational Approaches for Gene Identification Gautam B. Singh Primer3 on the WWW for General Users and for Biologist Programmers Steve Rozen andHelen Skaletsky Using the WWW to Supply the Molecular Biology Lab MaryAnn Labant and Roger Anderson Part 4. Computers and Molecular Biology: Issues and Constraints Network Computing: Restructuring How Scientists Use Computers and What We Get Out of Them Brian Fristensky Computing with DNA Lila Kari and Laura F. Landweber Detecting Biological Patterns: The Integration of Databases, Models, and Algorithms Gautam B. Singh Part 5. Teaching Bioinformatics and Keeping Up-to-Date with the Literature Design and Implementation of an Introductory Course for Computer Applications in Molecular Biology and Genetics Stephen A. Krawetz The Virtual Library I: Searching MEDLINE Keir Reavie The Virtual Library II: Science Citation Index and Current Awareness Services Keir Reavie The Virtual Library III: Electronic Journals, Grants, and Funding Information Keir Reavie

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