Origin and evolution of the vertebrate immune system
Author(s)
Bibliographic Information
Origin and evolution of the vertebrate immune system
（Current topics in microbiology and immunology, 248）
Springer, c2000
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Note
Includes bibliographical references
Description and Table of Contents
Description
The book presents the current knowledge, ideas and speculations about the origin of the adaptive immune system and its evolution. The accumulation of genetic, molecular and biological data across various classes of vertebrates and phyla within the animal kingdom has helped elucidate major elements of genetic conservation and specific variations on that theme. Several scenarios linking together genome evolution and the origin of receptors and the differentiation of lymphocyte lineage are now envisioned at a much more general and integrated level than before. The volume is a collection of chapters centered around the phylogeny of the immune system written by scientists. It presents a mix of subjects and new approaches in the form of reviews. The book delineates the current and controversial issues in this area.
Table of Contents
Bridge to Invertebrates.- New Approaches Towards an Understanding of Deuterostome Immunity.- The Antimocrobial Host Defense of Drosophila.- Origin and Evolution of the Complement System.- Genome Paralogy.- Phylogeny of Lower Vertebrates and Their Immunological Structures.- Recombination-Activating Genes, Transposition, and the Lymphoid-Specific Combinatorial Immune System: A Common Evolutionary Connection.- Transcription Factor Expression in Lymphocyte Development.- The Phylogenetic Origin of Antigen-Specific Receptors.- Immunoglobulin Isotypes: Structure, Function, and Genetics.- Evolution of Vertebrate Immunoglobulin Variable Gene Segments.- The Immune System of Cartilaginous Fish.- Immune-Type Diversity in the Absence of Somatic Rearrangement.- Evolution and Somatic Diversification of Immunoglobulin Light Chains.- Evolution of the T Cell Receptor Signal Transduction Units.
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