Principles of molecular oncology
著者
書誌事項
Principles of molecular oncology
Humana Press, c2000
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Award winning basic scientists and clinical researchers summarize the wealth of new molecular knowledge that sees cancer as a 'disease process' involving key regulatory pathways. Emphasizing prevention, early diagnosis, prognosis, and treatment, these authoritative experts from around the world illuminate the variety of molecular markers to be found, interpret what is known about diseased regulatory pathways, and examine those future research directions likely to realize the promise of molecular therapy. From their presentations, readers will gain an understanding of why current therapies fail, and of the new processes now available to identify specific molecular targets for optimal therapeutic efficacy. Comprehensive and path-breaking, "Principles of Molecular Oncology" offers both basic and clinical oncologists not only a bold synthesis of the rapid and complex advances in molecular biology that are transforming our knowledge of cancer, but also a highly practical guide to today's strategies for its diagnosis and treatment.
目次
Part I. Molecular Markers. Selecting the Right Targets for Cancer Therapy, Miguel H. Bronchud and William P. Peters. Clinical Importance of Prognostic Factors: Moving from Scientifically Interesting to Clinically Useful, Daniel F. Hayes. Genetic Markers in Sporadic Tumors, S. Birindelli, A. Aiello, C. Lavarino, G. Sozzi, Silvana Pilotti, and Marco A. Pierotti. Cellular and Tissue Markers in Solid Tumors, Thomas Lindahl, Torbjon Norberg, Gunnar A...strom, Sigrid Sjogren, and C. Jonas Bergh. Circulating Tumor Markers, Alan Horwich and Gill Ross. Part II. Diseased Regulatory Pathways. Growth Factor-Signaling Pathways in Cancer, Daniel Kalderon. Estrogen Action and Breast Cancer, Hong Liu and V. Craig Jordan. Cyclin-Dependent Kinases and Their Regulators as Potential Targets for Anticancer Therapeutics, Leonardo Brizuela, Jeno Gyuris, and Muzammil Mansuri. Apoptosis Pathways: Clinical Relevance, Caroline Archer, Peter Trott, and Mitchell Dowsett. DNA Repair Pathways: Mechanisms and Defects in the Maintenance of Genome Stability, Murray O. Robinson. Angiogenesis Switch Pathways, Jaume Piulats and Francesc Mitjans. Invasion and Metastasis, Maria Rosa Bani and Rafaella Giavazzi. Molecular Pathways of Drug Resistance, Christos Tolis, Carlos G. Ferreira, Herbert M. Pinedo, and Giuseppe Giaccone. Part III. Future Directions. Antitumor Immunity as Therapy for Human Cancer, Angelo A. Cardoso. Emerging Technologies: Molecular Targets and the Drug Delivery Process, Mathew Moyle and Michael Palazzolo, Emerging Molecular Therapies for Cancer, Karol Sikora. Emerging Molecular Therapies: Small-Molecule Drugs, Paul Workman. Glossary. Index.
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