Neurotransmitter release
著者
書誌事項
Neurotransmitter release
（Frontiers in molecular biology, 23）
Oxford University Press, 1999
- : hbk
- : pbk
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注記
Includes bibliographical references and index
内容説明・目次
- 巻冊次
-
: pbk ISBN 9780199637669
内容説明
Understanding the mechanisms that underlie brain activity and function remains one of the major frontiers of biology. All the processes of how we co-ordinate our movements, sense our surroundings, react to stimuli and learn and retain information rely on complicated networks of neurons that communicate with each other and their targets. This fast and accurate intercellular signalling most occurs at synapses, specialized processes of neurons that release chemical
signals, called neurotransmitters. Neurotransmitters: Frontiers in Molecular Biology will provide the reader with extensive background information on neurotransmitter release. It takes a multidisciplinary approach, but does not assume previous knowledge having basic introductions to most topics.
Topics however are covered in enough detail to be of interest to experts in the field. Throughout, emphasis is placed on the rationale by which proteins are assigned specific functions rather than just providing facts about function. The first chapter provides an introduction to the basic features and properties of the synapse and is followed by a chapter detailing several important techniques used to elucidate various aspects of release. Chapters 3 describes many of the biochemical approaches
used to identify proteins involved in neurotransmitter release and then chapters 4 and 5 focus on more specific aspects of synaptic transmission: the proteins that transport neurotransmitters and the role of phosphlipids in the process. The next five chapters concentrate on approaches to unravel the
function of many proteins in vivo by using toxins, giant squid axons, C. elegans, Drosophila, and mice. The final chapter summarizes current knowledge on endocytosis and recycling. Knowledge of the molecular mechanisms underlying neurotransmitter release has expanded tremendously over the last 10 years. Many of the proteins involved have been isolated, but their roles have yet to be determined. These discoveries will be a major challenge and it is therefore the major
aim of this book not only to provide information but also to generate excitement.
目次
- Preface
- List of Contributors
- 1. An overview of neurotransmitter release
- 2. Techniques for elucidaing the secretory process
- from Ca++ entry to exocytosis
- 4. The role of phospholipids in neurosecretion
- 5. Neurotransmitter transporters
- 6. Toxins that affect neurotransmitter release
- 7. Functional studies of presynaptic proteins at the squid giant synapse
- 8. Studying mutants that affect neurotransmitter release in C. elegans
- 9. Dissecting the molecular mechanisms of neurotransmitter release in Drosophila
- 10. Genetic analysis of neurotransmitter release in mice and humans
- 11. Synaptic vesicle endocytosis and recycling
- Index
- 巻冊次
-
: hbk ISBN 9780199637676
内容説明
Understanding the mechanisms that underlie brain activity and function remains one of the major frontiers of biology. All the processes of how we co-ordinate our movements, sense our surroundings, react to stimuli and learn and retain information rely on complicated networks of neurons that communicate with each other and their targets. This fast and accurate intercellular signalling mostly occurs at synapses, specialized processes of neurons that release chemical signals, called neurotransmitters. This volume provides the reader with extensive background information on neurotransmitter release. It takes a multidisciplinary approach, but does not assume previous knowledge having basic introductions to most topics. Topics however are covered in enough detail to be of interest to experts in the field. Throughout, emphasis is placed on the rationale by which proteins are assigned specific functions rather than just providing facts about function.
目次
- 1: Kelly: An overview of neurotransmitter release
- 2: Fisher and Oberhauser: Techniques for elucidaing the secretory process
- from Ca++ entry to exocytosis
- 3: Hazuka, Foletti and Scheller:
- 4: Martin: The role of phospholipids in neurosecretion
- 5: Krants, Chaudhry and Edwards: Neurotransmitter transporters
- 6: O'Kane, Schiavo and Sweeney: Toxins that affect neurotransmitter release
- 7: Burns and Augustine: Functional studies of presynaptic proteins at the squid giant synapse
- 8: Nonet: Studying mutants that affect neurotransmitter release in C. elegans
- 9: Pennetta, Wu and Bellen: Dissecting the molecular mechanisms of neurotransmitter release in Drosophila
- 10: Lloyd & Bellen: Genetic analysis of neurotransmitter release in mice and humans
- 11: Zhang & Ramaswami: Synaptic vesicle endocytosis and recycling.
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