CiNii 図書 - Oligosaccharides : their synthesis and biological role

Carbohydrates have attracted a great deal of research interest in recent years from both synthetic chemists and glycobiologists. As a result they are now associated with a plethora of important biological processes and have been implicated in the onset and progress of many lethal diseases. They have therefore been identified as novel targets of therapeutic importance. This book, which is aimed at synthetic and medicinal chemists, hopes to introduce both undergraduates and research students to the chemistry and biology of carbohydrates. The book investigates methods for synthesising carbohydrates in a systematic and logical manner and provides real examples from the literature to exemplify the procedures introduced. Both traditional and modern methods for synthesising carbohydrates, including enzymatic and solid-phase techniques, are discussed.

CHAPTER 1: INTRODUCTION
Location of oligosaccharides
Therapeutic potential
Nomenclature
Structural representation
Problems associated with oligosaccharide assembly
Further reading
CHAPTER 2: BIOLOGICAL ROLES OF OLIGOSACCHARIDES
Biosynthesis of some biologically important oligosaccharides
Carbohydrates as carriers of biological information
Lectins: Carbohydrate binding proteins
Diseases in which oligosaccharides play an important role
Further reading
CHAPTER 3: SYNTHESIS OF CARBOHYDRATE ACCEPTORS
General introduction to protecting group strategies
Specific protecting group strategies
Selection protection reactions
Synthesis of branched chain oligosaccharides
Further reading
CHAPTER 4: SYNTHESIS OF CARBOHYDRATE DONORS
Glycosyl acetates and thioglycosides
Glycosyl halides
Glycosyl selenides
Trichloroacetimidates
n-Pentyl glycosides
Vinyl glycosides
Glycals
Further reading
CHAPTER 5: ASSEMBLY OF OLIGOSACCHARIDES
Methods to control the configuration of newly formed anomeric bonds
Synthesis of beta-linked mannopyranosides
One pot synthesis of oligosaccharides
Further reading
CHAPTER 6: LITERATURE EXAMPLES OF OLIGOSACCHARIDES
An efficient synthesis of a high mannose type nonasaccharide
Stereoselective construction of the tetrasaccharyl cap portion of Leishmania lipophosphoglycan
A highly convergent synthesis of the tetragalactose moiety of the glycosyl phosphatidyl inositol anchor of the variant surface glycoprotein of Trypanosoma brucei
Synthesis of sialyl-Lewis
Further reading
CHAPTER 7: ALTERNATIVE STRATEGIES FOR SYNTHESISING OLIGOSACCHARIDES
Enzymatic synthesis of oligosaccharides
Polymer supported synthesis of oligosaccharides
Specific examples of polymer supported synthesis
Polymer supported synthesis employing enzymes
Further reading

巻冊次: :hbk ISBN 9780198502654

内容説明

Carbohydrates are associated with a plethora of important biological processes and have been implicated in the onset and progress of many lethal diseases. They have attracted a great deal of recent research interest from both synthetic chemists and glycobiologists, and have been identified as novel targets of therapeutic importance. This book, which is aimed at synthetic and medicinal chemists, hopes to introduce both undergraduates and research students to the chemistry and biology of carbohydrates. The book investigates methods for synthesising carbohydrates in a systematic and logical manner and provides real examples from the literature to exemplify the procedures introduced. Both traditional and modern methods for synthesising carbohydrates, including enzymatic and solid- phase techniques, are discussed.

CHAPTER 1: INTRODUCTION
CHAPTER 2: BIOLOGICAL ROLES OF OLIGOSACCHARIDES
CHAPTER 3: SYNTHESIS OF CARBOHYDRATE ACCEPTORS
CHAPTER 4: SYNTHESIS OF CARBOHYDRATE DONORS
CHAPTER 5: ASSEMBLY OF OLIGOSACCHARIDES
CHAPTER 6: LITERATURE EXAMPLES OF OLIGOSACCHARIDES
CHAPTER 7: ALTERNATIVE STRATEGIES FOR SYNTHESISING OLIGOSACCHARIDES
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Oligosaccharides : their synthesis and biological role

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