Clostridium difficile

Author(s)

    • Aktories, K.
    • Wilkins, T. D.

Bibliographic Information

Clostridium difficile

edited by K. Aktories and T. D. Wilkins

(Current topics in microbiology and immunology, 250)

Springer, c2000

Available at  / 17 libraries

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Note

Includes bibliographical references

Description and Table of Contents

Description

Clostridium difficile has been recognized as the cause of a broad spectrum of enteric disease ranging from mild antibiotic-associated diarrhea to pseudomembranous colitis. This volume gives new insights into the microbiology, diagnostics and epidemiology of Clostridium difficile and describes recent strategies in treatment of diseases caused by this agent. Main parts of the volume are devoted to Clostridium difficile toxins A and B which are the major virulence factors. The molecular biology, biochemistry, pharmacology and cell biology of these toxins which are the prototypes of a new family of large clostridial cytotoxins is described in great detail. Clostridium difficile toxins act as glucosyltransferases to inactivate small GTP-binding proteins of the Rho family which are involved in regulation of the actin cytoskeleton, cell adhesion and various signaling processes.

Table of Contents

Microbiology, Epidemiology and Diagnosis of Clostridium difficile Infection.- Genetics of Clostridium difficile Toxins.- Molecular Mode of Action of the Large Clostridial Cytotoxins.- Cytotoxic Effects of the Clostridium difficile Toxins.- Large Clostridial Cytotoxins as Tools in Cell Biology.- Pathogenesis and Clinical Manifestations of Clostridium difficile Diarrhea and Colitis.- Treatment of Clostridium difficile-Associated Diarrhea and Colitis.-

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    Available at 22 libraries

Details

  • NCID
    BA47560669
  • ISBN
    • 3540672915
  • Country Code
    gw
  • Title Language Code
    eng
  • Text Language Code
    eng
  • Place of Publication
    Berlin ; Tokyo
  • Pages/Volumes
    vi, 143 p.
  • Size
    24 cm
  • Parent Bibliography ID
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