Eicosanoids in invertebrate signal transduction systems
著者
書誌事項
Eicosanoids in invertebrate signal transduction systems
Princeton University Press, c2000
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注記
Includes bibliographical references (p. [249]-272) and index
内容説明・目次
内容説明
This volume generates a new paradigm for researching and understanding the biological meaning of eicosanoids. Eicosanoid is a general term for oxygenated metabolites of certain polyunsaturated fatty acids. The compounds are extremely important in human biology, in which they are well understood. Their importance to humans, however, has tended to overshadow their broader biological significance. David Stanley seeks to change that in this book, providing a general sketch of the medical background on eicosanoids and then developing a detailed critical treatment of eicosanoid actions in invertebrates and some lower vertebrates. Stanley looks at the role of eicosanoids in, for example, invertebrate reproduction, immunity, and ion transport physiology. As he explains, eicosanoids also mediate important ecological interactions, particularly host-parasite interactions. Drawing on these physiological and ecological actions, the book develops a "biological paradigm," under which we understand that eicosanoids probably exert important actions in most, if not all, animals. Because eicosanoids mediate crucial events in the lives of animals, they are endowed with unusual explanatory power.
Research designed to increase our understanding of eicosanoids has thus yielded and will continue to yield important new information about animal biology. In addition to representing a major advance in our understanding of eicosanoids in animals, this book serves as an unusually comprehensive and accessible introduction to eicosanoid research in general.
目次
Foreword by Ralph W. Howard ix Acknowledgments xi Chapter 1. Introduction: A Theory of the Biological Significance of Eicosanoids 3 Chapter 2. Eicosanoid Structures and Biosynthesis 11 The Mammalian Model of Eicosanoid Biosynthesis 12 Chapter 3. Polyunsaturated Fatty Acids 34 Essential Fatty Acids 34 C20 Polyunsaturated Fatty Acids in Insects 39 The Complete Biosynthesis of 18:2n-6 in Insects 39 Biosynthesis of C20 Polyunsaturated Fatty Acids 43 Patterns of Polyunsaturated Fatty Acid Metabolism in Insects 50 Chapter 4. Eicosanoids in the Reproductive Biology of Invertebrates 55 Eicosanoids in Insect Reproduction 55 Eicosanoids as the Barnacle Hatching Factor 74 Eicosanoids in Scallop Reproduction 79 Prostaglandins in Crayfish Vitellogenesis 82 Prawns 86 Eicosanoids in the Reproduction of Molluscs 87 Prostaglandins Influence Organismal-Level Events through Their Actions on Cells in the CNS 92 Eicosanoid Actions at the Cellular Level 94 Chapter 5. Eicosanoids in Invertebrate Immunity 109 Eicosanoids in Insect Cellular Immune Reactions to Bacterial infections 111 Eicosanoids Mediate Clearance of Injected Bacteria from Insect Heinolymph Circulation 112 Eicosanoids Mediate Nodulation Reactions to Bacterial Infections 117 Hypothesis: Eicosanoids Mediate Nodulation Reactions to Bacterial Infections in Most, If Not All, Insect Species 124 The Biochemistry of Eicosanoid Systems in Immune Tissues 133 Chapter 6. Eicosanoids in Invertebrate Ion Transport Physiology 152 Chapter 7. Emerging Eicosanoid Actions 173 Eicosanoids in Invertebrate Temperature Biology 173 Eicosanoids in Insect Peptide Hormone Signal Transduction 178 Eicosanoids in Development and Regeneration in Hydroids 183 Chapter 8. Eicosanoids Mediate Ecological Interactions 188 Eicosanoids in Predator Avoidance 188 Eicosanoids in Host-Parasite Interactions 194 Prostaglandin Biosynthesis Inhibitors in Insect Defensive Secretions: Do these Compounds Act in Insect Chemical Ecology? 231 Chapter 9. A Research Prospectus: Approaching the Frontiers 235 How Do Eicosanoids Work? 236 Understanding Departures from the Mammalian Background 237 The Enzymes Associated with Eicosanoids 239 Eicosanoids and Neurobiology 241 The Molecular Biology of Eicosanoids 243 An Epilogue 244 Abbreviations Used in References 245 References 249 Taxonomic Index 273 Subject Index 275
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