Serotoniergic neurons and 5-HT receptors in the CNS
著者
書誌事項
Serotoniergic neurons and 5-HT receptors in the CNS
Springer, 1999
2nd printng 1999, Springer study ed
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注記
Originally published in the Handbook of experimental pharmacology, v. 129 -- t. p. verso
内容説明・目次
内容説明
In 1966, Vittorio Erspamer, the editor of the first monograph within the Handbook of Experimental Pharmacology series that dealt with 5-hydroxy- tryptamine (Vol. XIX) wrote in the Preface: "In a decade of intense and dedicated work, an immense amount of experimental data has been collected, the significance of which ...has spread into all fields of biology and medi- cine ...". Three decades later, a dramatic further increase in our knowledge of all neuroscientific aspects of the serotoninergic system in the CNS has been achieved, and we are witnessing persisting interest in the biology of serotonin of scientists working in various basic biomedical and clinical disciplines. The scientific advance was made possible by significant improvements in analytical and morphological technologies of high sensitivity and cellular/subcellular resolution (e. g. , patch clamp techniques, in vivo microdialysis, electrophysi- ological recording techniques, quantitative ligand autoradiography, immuno- histochemistry, cytochemistry, catalytic enzyme histochemistry, and PET / SPECT techniques) and in molecular biology (e. g.
, in situ hybridization, PCR cloning, DNA transfection studies, and targeted gene disruption). Particular progress has been made in the anatomy, physiology, and pharmacoogy of ' serotoninergic neurons and their modulatory role in brain functions, in s ~roto- nin receptors and their transduction mechanisms, and in the potential role of serotonin in neuropsychiatric diseases, such as eating disorders, antisocial personality disorders, obsessive-compulsive disorder, seasonal affective disor- der, and major depression.
目次
- Development and Adult Plasticity of Serotoninergic Neurons and Their Target Cells - Anatomy of Central Serotoninergic Projection Systems - Physiology and Pharmacology of Brain S.N. - Tryptophan Hydroxylase: Molecular Biology and Regulation - Molecular Analysis of Serotonin Packaging into Secretory Vesicles - Regulation of the Environment of the Interior of Serotonin-Storing Vesicles - Molecular Biology and Transductional Characteristics of 5-HT Receptors - 5-Hydrotryptamine Receptor Histochemistry: Comparison of Receptor mRNA Distribution and Radioligand Autoradiography in the Brain - The Main Features of Central 5-HT1A Receptors - Functional Neuropharmacology of Compounds Acting at 5-HT 1B/D Receptors - 5-HT-Moduline, an Endogenous Peptide Modulating Serotoninergic Activity via a Direct Interaction of 5-HT 1B/1D Receptors - Regulation of 5-HT Release in the CNS by Presynaptic 5-HT Autoreceptors and by 5-HT Heteroreceptors - Behavioral Consequences of 5-HT1B Receptors Gene Deletion - Pharmacology of 5-HT2 Receptors - Regulation of 5-HT2A Receptor at the Molecular Level
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