Pharmacology of cytokines
著者
書誌事項
Pharmacology of cytokines
Oxford University Press, 2000
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注記
XISBN "0198500424"-- back cover
Includes bibliographical references and index
内容説明・目次
内容説明
Cytokines are polypeptide mediators which act as communication signals among cells of the immune system as well as among other cells and tissues in the body. They are a heterogeneous and complex group and include interferons, tumor necrosis factor and chemokines. They play a key role in homeostasis and in host defence and are involved in such inflammatory and autoimmune diseases such as rheumatoid arthritis as well as infectious diseases such as HIV infection and septic shock. Modulation of the production and action of cytokines, as well as their exploitation as therapeutic agents, has been the object of intense and competitive research. This book overviews the field of cytokine research and describes the various approaches that have been taken to develop the pharmacology of these novel mediators. The pharmacology of cytokines is an area which is entering the clinical arena. The book, in the framework of the immunobiology of cytokines, examines the interactions with the cytokine system of a variety of compounds ranging from simple synthetic chemicals to biotechnological products .
This book is intended for graduate students and researchers in immunology, both in academia and more importantly in the pharmaceutical industry.
目次
Preface. 1: Cytokines: a world apart. Part I: Pharmacology. 2: Inhibitors of cytokine production and action. 3: Inhibitors of cytokine processing. 4: Receptor antagonists. 5: Antibodies and soluble receptors. 6: Anti-inflammatory/immunosupressive cytokines. Part II: Pharmacology in a context. 8: Nervous system. 9: Cardiovascular system. 10: Cancer. 11: Liver and lung. 12: Skin. 13: Sepsis. Appendix: Interferon Beta
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