Complement regulatory proteins
著者
書誌事項
Complement regulatory proteins
Academic Press, c1999
大学図書館所蔵 全7件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
From small beginnings in the early 1970s, the study of complement regulatory proteins has grown in the last decade to the point where it dominates the complement field. This growth has been fueled by the discovery of new regulators, the cloning of old and new regulators, the discovery that many of the regulators are structurally and evolutionarily related to each other and the development of recombinant forms for use in therapy. There are now more proteins known to be involved in controlling the complement system than there are components of the system and the list continues to grow. The time is ripe for a comprehensive review of our current knowledge of these intriguing proteins. This book does just that. The first few chapters discuss the "nuts-and-bolts" of the complement regulators, describing their structures, functional roles and modes of action. The roles of the complement regulators in vivo are then described, focusing on the consequences of deficiency, roles in the reproductive system, interactions with pathogens and exploitation for therapy. The interesting developments in defining the complement regulators expressed in other species are also discussed. The book is written as a monograph, albeit by two people. The text is as readable as possible without compromising on scientific accuracy and completeness. The conversational style very evident in some sections is deliberate! Placing all references in a single bibliography at the end of the text further improves readability. The reader will go to the book to discover a specific fact but be persuaded to read more and derive pleasure from the process. The authors' enthusiasm for the subject comes over strongly in the text, and this enthusiasm proves infectious.
目次
The Complement System: A Brief Overview:Introduction.Activation of C.Physiological Roles of C.Involvement of C in Pathology.Why a Book on C Regulators?Regulation in the Complement System:Introduction.History.Control of Activation Pathways.Control in the Membrane Attack Pathway.Control of the Anaphylactic Peptides.Summary.Regulation in the Activation Pathways:Regulation of C1.Regulators Encoded in the RCA Gene Cluster.Other Regulators of the Activation Pathways.Regulation in the Terminal Pathway:Introduction.Fluid-Phase Regulators of the Terminal Pathway.Membrane Regulators of the Terminal Pathway.Recovery from C Membrane Attack.Concluding Remarks.Deficiencies of Complement Regulators:Introduction, Deficiency of C1 Inhibitor (C1inh).Deficiencies of Fluid-Phase C3 Convertase Regulators.Deficiencies of Fluid-Phase Membrane Attack Pathway Regulators.Deficiencies of Membrane Regulators of C.Concluding Remarks.Complement Regulation in the Reproductive System:Introduction.Role of C Inhibitors in the Protection of Sperm.Role of C Regulators in Protection of the Fetus.The Role of MCP in Fertilization.Concluding Remarks.Complement Regulators and Micro-Organisms:Introduction.Complement Regulators as Receptors for Microorgansims.Hijacking of Complement Regulators by Microorganisms.Molecular Mimicry.C5a-Peptidase/C5a-ASE.Conclusions.Complement Regulatory Proteins in Other Species:Introduction.Regulators of the Activation pathways.Regulators of the Terminal Pathway.Manipulation of Membrane C Regulators In Vivo.Complement Regulators in Therapy:Introduction.Therapy with Soluble C Regulators.Antibodies Against C Components as Therapeutics.Complement Regulators in Xenotransplantation.Anti-CRP Antibodies and Therapy.Concluding Remarks.Bibliography.
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