Pharmacology
Author(s)
Bibliographic Information
Pharmacology
Churchill Livingstone, c1999
4th ed
- :standard ed.
- :international ed.
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Note
Includes bibliographical references and index
illustrations by Peter Lamb
Description and Table of Contents
Description
The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently.
Table of Contents
Section 1 General Principles How drugs act: general principles How drugs act: molecular aspects Method and measurement in pharmacology Absorption and distribution of drugs Drug elimination and pharmokinetics Section 2 Chemical Mediators Chemical mediators and the autonomic nervous system Cholinergic transmission Noradrenergic transmission Other peripheral mediators: 5-hydroxytryptamine and purines Peptides and proteins as mediators Nitric oxide Local hormones, inflammation and allergy Anti-inflammatory and immunosuppressant drugs Section 3 Drugs Affecting Major Organ Systems The heart The vascular system Atherosclerosis and lipoprotein metabolism Haemostasis and thrombosis The haemopoietic system The respiratory system The kidney The gastrointestinal system The endocrine pancreas and the control of blood glucose Obesity The pituitary and adrenal cortex The thyroid The reproductive system Bone metabolism Section 4 The Central Nervous System Chemical transmission and drug action in the central nervous system Amino acid transmitters Other transmitters and modulators Neurodegenerative disorders General anaesthetic drugs Anxiolytic and hypnotic drugs Antipsychotic drugs Drugs used in affective disorders Antiepileptic drugs and centrally acting muscle relaxants Analgesic drugs Central nervous system stimulants and psychotomimetic drugs Drug dependence and drug abuse Local anaesthetics and other drugs that affect ion channels Section 5 Chemotherapy of Infectious and Malignant Disease Basic principles of chemotherapy Cancer chemotherapy Antibacterial drugs Antiviral drugs Antifungal drugs Ant
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