Immunological mechanisms in asthma and allergic diseases
著者
書誌事項
Immunological mechanisms in asthma and allergic diseases
（Chemical immunology, v. 78）
Karger, 2000
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注記
Includes bibliographical references and indexes
"Symposium held on the occasion of Prof. A. Barry Kay's 60th Birthday and 20th year as Head of Department, London, June 24-25, 1999"
内容説明・目次
内容説明
This book explores the celllular and molecular mechanisms involved in asthma and allergic diseases, from basic immunology to the treatment of patients. Arising from a special symposium held to celebrate Professor A. Barry Kay's 20th anniversary as Head of the Department of Allergy and Clinical Immunology at the National Heart and Lung Institute, London, the publication presents 18 review articles by an impressive cross section of experts in the field. Topics considered include Th1 and Th2 cells, the regulation of Th2 cytokine transcription, the role of T cells in the immunopathogenesis of asthma, and MHC-restricted IgE-independent T-cell-induced late-phase responses in human subjects. Further chapters focus on eosinophil adhesion and activation, the role of C-C chemokines in the recruitment of eosinophils, and the interactions between eosinophils and fibroblasts. T-cell recruitment and T-cell interactions in cutaneous basophil hypersensitivity and fibrotic lung disease are discussed, as is the molecular pathology of allergic disease. Finally, treatment approaches are considered in chapters on the molecular basis of corticosteroid actions in asthma, immunosuppression in asthma, and immunotherapy of allergic diseases. Authoritative and up-to-date, this volume is recommended reading for anyone interested in the immunology and clinical aspects of asthma and allergy, in particular those involved in research for new treatments.
目次
- Scientific overview of 20 years' work in the Department of Allergy and Clinical Immunology under the guidance of professor A.B. Kay - D.S. Robinson
- regulation of Th2 cytokine gene transcription - P.Lavender, D. Cousins, T. Lee
- MHC-restricted, IgE-independent, allergen peptide-induced late asthmatic reactions - M. Larche
- the role of the T cell in the immunopathogenesis of asthma - C.J. Corrigan
- the Th1 and Th2 concept in atopic allergic disease - D.S. Robinson
- the bronchial epithelial origins of asthma, S.T. Holgate
- molecular basis for corticosteroid action in asthma - P.J. Barnes
- mast cell-eosinophil-fibroblast crosstalk in allergic inflammation - S.J. Smith, F. Levi-Schaffer
- the role of adhesion in eosinophil function - A.J. Wardlaw
- proposing Th2 DTH relevant to asthma - cutaneous basophil hypersensitivity then and now - P.W. Askenase
- novel immunosuppressants in asthma - O.M. Kon
- T-cell recruitment and specificity in allergic inflammation - A.J. Frew
- T cells and fibrosis - B.G. Marshall, R.J. Shaw
- molecular pathology of allergic diseases - P. Christodoulopoulos, S. Muro, Q. Hamid
- role of eotaxin and related C-C chemokines in allergy and asthma - T.J. Williams, P.J. Jose
- C-C chemokine expression in atopic and nonatopic asthma - S. Ying
- molecular mechanisms in eosinophil activation - R. Moqbel, P. Lacy
- immunotherapy for hayfever - S.R. Durham, S. Walker.
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