The neuropathology of schizophrenia : progress and interpretation
著者
書誌事項
The neuropathology of schizophrenia : progress and interpretation
（Oxford medical publications）
Oxford University Press, 2000
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The neuropathology of schizophrenia is one of the most controversial areas of research in psychiatry; however, in the last twenty years, there have been significant advances in our understanding of the topic. This book provides a much needed, balanced, comprehensive and up-to-date overview of this rapidly moving field. It starts by describing the findings derived from new imaging techniques and histological studies, focusing specifically on the morphology,
arrangement and connectivity of the neurons making up the cortical cytoarchitecture, a feature thought to be central to understanding the pathology. This is followed by critical appraisal of the various interpretations placed upon these findings, such as the neurodevelopmental hypothesis. Finally, there are
chapters considering the conceptual and methodological problems affecting the subject. This is a timely and unique book on this classic and controversial issue, with contributions from many of the leading international experts in the field.
目次
- Introduction
- 1. Structural imaging findings and macroscopic pathology
- 2. Hippocampal pathology
- 3. Cortical pathology: a new generation of quantitative microscopic findings
- 4. Synaptic pathology
- 5. Gliosis and its implications for the disease process
- 6. Cerebral asymmetry
- 7. Functional imaging and neural circuitry in schizophrenia
- 8. Neuropathology and the neurodevelopmental model
- 9. Cortical development and schizophrenia
- 10. The organization of cortical circuitry
- 11. Perspectives from other diseases and lesions
- 12. Animal models of schizophrenia
- 13. A sceptical view of the neuropathology of schizophrenia
- 14. Methodological issues
- 15. Neuropathological consequences of schizophrenia treatments
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