Cancer and the search for selective biochemical inhibitors

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書誌事項

Cancer and the search for selective biochemical inhibitors

E.J. Hoffman

CRC Press, c1999

  • alk. paper

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Cancer and the Search for Selective Biochemical Inhibitors examines the nonorthodox methods-particularly plant and herbal possibilities-for treating cancer. This book explores the theory of why and how alternative treatments of cancer should work, with an emphasis on the role of enzyme inhibitors, the basis for most modern drug therapy, including those which may be selective for cancer cell metabolism.

目次

  • Part I: The Biochemistry of Cancer and Its Treatment Introductory Remarks A Detailing of Enzyme-Catalyzed Biochemical Reactions Involved in Cell Metabolism Glycolysis, Lactic Acid or Lactate, Glutaminolysis, Tricarboxylic Acid Cycle Cancer Cells vs. Normal Cells Enzyme Inhibitors for Glycolysis, Lactate Formation, and Glutaminolysis in Tumor Cells Glycolysis, Lactate or Lactic Acid Formation, Glutaminolysis Tricarboxylic Acid Cycle: Enzyme Inhibitors to be Avoided Cofactors, Coenzymes, Vitamins, and Hormones Chemotherapy Drugs Purine and Pyrimidine Nucleotides
  • Enzyme Inhibitors in Chemotherapy
  • Sulfa Drugs
  • Antifolate Drugs
  • Irreversible Antimetabolites
  • Other Metabolites
  • Listings of Cytotoxic Chemotherapy Drugs The DNA/RNA Connection Thymidylate Synthase Inhibition
  • Dihydrofolate Reductase Inhibition
  • Other Inhibitors Gene Therapy and E coli Folic Acid Comparison with Conventional Chemotherapy
  • Clinical Trials Enzyme Changes DNA, RNA, and the Synthesis of Proteins DNA and Its Functions
  • RNA and Its Functions
  • Transcription, Translation
  • Proteins
  • Changes The Genetic Code Genetic Cancer Therapy Digestion Dietary Protein
  • Carbohydrates
  • Fats Proteases and Protease Inhibitors Protein Degradation Antibiotics DNA Replication DNA Alteration Repair, Carcinogen Identification
  • DNA Recombination
  • DNA Methylation Viruses and Subviruses Antiviral Agents Chemoprevention Comments References for Part I Part II: Plant Biochemistry and Cancer Introduction Cancer and Anticancer Agents Antibacterial and Antiviral Agents Antifungal and Miscellaneous Agents Plant Enzymes Bioactive/Toxic Plant Substances Glycosides Phenolics Flavonoids Proteins and Amino Acids Alkaloids The Functions of Alkaloids, Toxicity and Cancer Some Conclusions References for Part II Part III: Chemical Taxonomy Review of Medicinal Plant Literature Sources Some Anticancer Plants Noted in the United States Investigations in Other Countries Neo-Tropical Africa, Australia, India and Pakistan, East and Southeast Asia, China Plant Chemistry and Taxonomy Toxic/Medicinal Substances and Cancer The Genus Catharanthus A Chinese Protocol Other Information about Chinese Anticancer Agents Common Possibilities for Anticancer Agents References for Part III Part IV: Alkaloids as Medicines Introduction Classification of Alkaloids Alkaloids as Anticancer Agents Alkaloids as Antibacterial Agents Alkaloids as Antiviral Agents Alkaloids as Antifungal Agents Other Medicinal Uses for Alkaloids Toxicity versus Medical Benefits Screening Plants for Alkaloids Common Garden Vegetables and Alkaloids Plants and Plant Families Containing Potential Anticancer Agents, Notably Alkaloids Tobacco, Hemlock, Lupines, Potato, Locoweeds, Red Clover, Fescue, Ergot Alkaloids, Larkspur or Delphinium, Selenium Indicators, Jimsonweed A Review of Bioactive Plants and Plant Families References for Part IV Part V: Medicinal Uses of Fungi The Mycota or Fungi Mycetismus Mycotoxosis Medicinal Fungi and Cancer Antibiotics Antifungal vis-a- vis Anticancer Agents References for Part V Part VI: Biogenesis of Cancer Introductory Remarks Cancer Initiation, Enzymes, and Enzyme Inhibitors Melanoma, Other Developments Stress Proteins or Heat Shock Proteins and Molecular Chaperones Metastasis and Glycoproteins Intestinal Flora and Cancer Bacterial Metabolism of Carcinogens
  • Mutagens and Bowel Cancer
  • Other Considerations Digestive Metabolism Bacterial Metabolism of Protein and Endogenous Nitrogen Compounds
  • Metabolism of Fats, Bile Acids, and Steroids
  • Metabolism of Carbohydrates, Metabolism of Nitroso Compounds
  • Nitrate, Nitrite, and N-Nitroso Compounds
  • Metabolism of Toxic Metals
  • Dietary Fiber and Colon Microflora Lignans and Phyto-Estrogens Intense Sweeteners Hydrolysis and Other Interactions between Intenstinal Flora and Ingested Chemical Types Glycosides
  • Quinones
  • Flavonoids
  • Glycoside Sweeteners
  • Role in Drug Administration
  • Miscellaneous Glycosides
  • Esters All-Meat and All-Vegetarian Diets References for Part VI Part VII: Viruses and Cancer More about Viruses and Other Pathogens Retroviruses and Oncogenes Viruses and Degenerative Diseases Rhabdoviruses, e.g., Rabies Virus
  • Reoviruses Plant and Insect Viruses Fungal Viruses "Myco-" Microorganisms and Pleomorphism
  • Mychorrhiza
  • Plasmids
  • Killer Systems Bacterial and Protozoan Viruses Viruses in Animal Products Viruses in Meat and Poultry
  • Viruses in Milk
  • Viruses in Seafoods
  • Effect of Temperature
  • Drying
  • Effect of High Temperatures
  • Effect of Irradiation
  • Effect of Chemicals and Depuration The Tropical Connection Some Information Sources about Bioactive Plants in Neotropica
  • Diseases of the Tropics Immunity Vaccines
  • The Immune System
  • Immunization against Cancer References for Part VII Part VIII: Anticancer Agents as Enzyme Inhibitors and Other Issues Bioactive Plants as Enzyme Inhibitors A Review of Anaerobic Glycolysis Enzymes and Inhibitors for Anaerobic Glycolysis Cancer Initiation, Enzymes, and Enzyme Inhibitors Phytochemicals Which May Act Against Cancer Laetrile Again?
  • Other Bioactive Substances and Miscellaneous Agents Testing Procedures Anticancer Agents and Angiogenesis Plant or Herbal Remedies Challenged An Update on Plant or Other Substances as Enzyme Inhibitors Garlic and Allicin
  • Miscellaneous
  • Vitamins and Hormones as Enzyme Inhibitors Lactate Dehydrogenase Inhibitors Forms of Lactate Dehydrogenase
  • Aerobic versus Anaerobic Metabolism in the Body
  • Gluconeogenesis
  • Inhibition of Lactate Dehydrogenase Update on Glutaminolysis DHEA Objectives, Mileposts, and Roadblocks References for Part VIII Appendices Appendix A: Enzymes and Inhibitors for Glycolysis, Lactate Formation, and Glutaminolysis Appendix B: Enzymes and Inhibitors for the Tricarboxylic Acid Cycle and as Affecting Respiration Appendix C: Enzymes and Inhibitors Pertaining to Chemotherapy Appendix D: Enzymes and Inhibitors for Enzymatic Changes Appendix E: DNA Enzymes and Inhibitors Appendix F: RNA Enzymes and Inhibitors Appendix G: Protease Enzymes and Inhibitors Appendix H: A Worldwide Selection of Anticancer Plants Appendix I: Antibacterial Plant Agents Appendix J: Anviral Plant Agents Appendix K: Antifungal Plant Agents Appendix L: Miscellaneous Plant Agents Appendix M: Some Bioactive Plants Found in the United States Appendix N: Anticancer Plants of the Neo Tropics Appendix O: Anticancer Plants of Africa Appendix P: Bioactive/Poisonous Plants Found in Australia Appendix Q: Anticancer Plants of India and Pakistan Appendix R: Anticancer Plants of East and Southeast Asia Appendix S: Anticancer Plants from China Appendix T: Chemical Taxa of Medicinal Plants Appendix U: Plant Families Listed in Hartwell and Cordell Appendix V: Bioactive/Toxic Plants Found in the United States Appendix W: Phytochemicals Appendis X: Agents That Affect Angiogenesis Appendix Y: Update on Enzymes and Inhibitors Involved in Anaerobic Glycolysis Appendix Z: Vitamins and Hormones as Enzyme Inhibitors

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