The cytokine network
著者
書誌事項
The cytokine network
（Frontiers in molecular biology, 25）
Oxford University Press, c2000
- : hbk
- : pbk
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注記
Includes bibliographical references and index
内容説明・目次
- 巻冊次
-
: pbk ISBN 9780199637027
内容説明
Cytokines are soluble mediators of intercellular communication. They contribute to a chemical signalling language that regulates development, tissue repair, haemopoiesis, inflammation and the immune response. Potent cytokine polypepides have pleiotropic activities and functional redundancy. They act in a complex network where one cytokine can influence the production of, and response to, many other cytokines. In the past five years, this bewildering array of more
than 100 effector molecules and associated cell surface receptors has been simplified by study of cytokine and cytokine receptor structure; elucidation of convergent intracellular signalling pathways; and molecular genetics, and targeted gene disruption to 'knock-out' production of individual
cytokines in mice. It is also now clear that the pathophysiology of infectious, autoimmune and malignant disease can be partially explained by the induction of cytokines and the subsequent cellular response. Viral homologues exist for many cytokines and receptors and genetic variations in cytokine production may influence response to pathogenic stimuli. Cytokine and cytokine antagonists have shown therapeutic potential in a number of chronic and acute diseases. The Cytokine Network:
Frontiers in Molecular Biology is not a survey of individual cytokines, but guides the reader through the latest research on the cytokine network as a whole covering genomics, signalling pathways, control of the immune response, and therapeutics.
目次
- Preface
- A Genomics Approach to Cytokine Discovery
- Cytokine Signal Transduction
- Cytokine and the Th1/Th2 Paradigm
- Chemokines
- Cytokines and Cytokine Receptors Encoded by Viruses
- Genetic Variation in Cytokines and Relevance to Inflammation and Disease
- Therapeutic Manipulation of the Cytokine Network
- Index
- 巻冊次
-
: hbk ISBN 9780199637034
内容説明
Cytokines are soluble mediators of intercellular communication. They contribute to a chemical signalling language that regulates development, tissue repair, haemopoiesis, inflammation and the immune response. Potent cytokine polypepides have pleiotropic activities and functional redundancy. They act in a complex network where one cytokine can influence the production of, and response to, many other cytokines. During the 1990s, this bewildering array of more than 100 effector molecules and associated cell surface receptors has been simplified by study of cytokine and cytokine receptor structure; elucidation of convergent intracellular signalling pathways; and molecular genetics, and targeted gene disruption to "knock-out" production of individual cytokines in mice. It is also now clear that the pathophysiology of infectious, autoimmune and malignant disease can be partially explained by the induction of cytokines and the subsequent cellular response. Viral homologues exist for many cytokines and receptors and genetic variations in cytokine production may influence response to pathogenic stimuli.
目次
- Rosen, et al: A Genomics Approach to Cytokine Discovery
- Nelms: Cytokine Signal Transduction
- Brennan and Feldmann:
- Romagnani: Cytokine and the Th1/Th2 Paradigm
- Mantovani and Sozzani: Chemokines
- Symons and Smith: Cytokines and Cytokine Receptors Encoded by Viruses
- Duff: Genetic Variation in Cytokines and Relevance to Inflammation and Disease
- Balkwill: Therapeutic Manipulation of the Cytokine Network.
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