From DNA damage and stress signalling to cell death : poly-ADP-ribosylation reactions

Author(s)

• Murcia, Gilbert de
• Shall, S. (Sydney)

Bibliographic Information

From DNA damage and stress signalling to cell death : poly-ADP-ribosylation reactions

Gilbert de Murcia, Sydney Shall, editors

Oxford University Press, c2000

• alk. paper

Note

Includes bibliographical references and index

Description and Table of Contents

Description

Over the last 10 years, it has become apparent that poly-ADP ribosylation reactions govern some of the fundamental processes of life. PARP 1 is a highly conserved enzyme and a constitutive factor of the DNA damage surveillance network and plays an essential role in the protection and processing of DNA ends as they arise in DNA damage, repair, and recombination. The recent discovery of multiple members of the PARP family suggests an expanded role for poly-ADP ribosylation reactions. Poly ADP-ribosylation Reactions contains basic knowledge of poly-ADP ribosylation reactions and reviews the most recent molecular (including the crystal structure) and genetic (including knock out mice) approaches that have contributed to our understanding of the physiological role PARP 1 and its homologues. A discussion of the novel pharmacological role of inhibition of PARP is also included. The final chapter outlines future directions in the field of cellular responses to DNA damage. Its comprehensive coverage of the multiple aspects of this type of post-translational modification induced by DNA damage mean this book will serve as reference for both new and experienced investigators.

Table of Contents

• ADP-RIBOSE POLYMER METABOLISM
• POLY ADP-RIBOSE POLYMERASE: STRUCTURE AND FUNCTION
• MOLECULAR AND GENETIC APPROACHES: BIOLOGICAL SIGNIFICANCE OF POLY ADP-RIBOSYLATION REACTIONS
• POLY ADP-RIBOSE POLYMERASE AND CELL DEATH
• ACTIVATION OF POLY ADP-RIBOSE POLYMERASE IN THE PATHOGENESIS OF ISCHAEMIA REPERFUSION INJURY
• NEW POLY ADP-RIBOSE POLYMERASE INHIBITORS FOR RADIOTHERAPY AND CHEMOTHERAPY OF CANCER
• PERSPECTIVES

by "Nielsen BookData"

Details

• NCID: BA50278272
• ISBN:
  • 0198506333
• LCCN: 00058032
• Country Code: us
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: New York
• Pages/Volumes: xxii, 238 p.
• Size: 24cm
• Classification:
  • LCC : QP625.A29
  • DC21 : 572/.7921
• Subject Headings:
  • LCSH : ADP-ribosylation