Gene therapy : therapeutic mechanisms and strategies

著者

• Templeton, Nancy Smyth
• Lasic, D. D.

書誌事項

Gene therapy : therapeutic mechanisms and strategies

edited by Nancy Smyth Templeton, Danilo D. Lasic

Marcel Dekker, c2000

タイトル別名

Gene therapy

注記

Includes bibliographical references and index

内容説明・目次

内容説明

This text covers all aspects of gene therapy, including basic principles, viral and nonviral delivery systems, targeted diseases, regulatory issues, and FDA requirements. It investigates genetic bullets to block HIV-1 replication and genetic guns to deliver antiviral agents.

目次

• Viral delivery and therapeutic strategies: retroviral vectors for gene therapy
• adenovirus vectors for gene therapy
• adeno-associated virus and adeno-associated virus vectors for gene delivery
• ex vivo gene therapy using myoblasts and regulatable retroviral vectors
• design and use of herpes simplex viral vectors for gene therapy
• alphavirus-based vectors for vaccine and gene therapy applications. Nonviral delivery and therapeutic strategies: gene delivery with polyethylenimine
• receptor-mediated gene transfer
• modification of melanoma cells via ballistic gene therapy for vaccination
• polymer-encapsulated cells for gene therapy
• molecular interactions in lipids, DNA, and DNA-lipid complexes
• bio-organic colloids - macromolecules, DNA, self-assembled particles and their complexes
• synthetic virus systems for systemic gene therapy. Other therapeutic strategies and regulatory aspects: gene therapy applications of ribozymes
• antisense oligonucleotide-based therapeutics
• selectable markers for gene therapy
• suicide gene therapy
• regulatory aspects of gene therapy. Disease targets and therapeutic strategies: gene transfer into haematopoietic stem cells
• gene therapy for haematopoietic disorders
• gene therapy for cardiovascular disease and vascular grafts
• gene therapy for cancer
• barriers to efficient airway epithelial gene transfer -lessons from cystic fibrosis
• gene transfer to the central nervous system
• principles of gene therapy for inborn errors of metabolism
• gene therapy and HIV-1 infection
• gene delivery to the skin
• DNA vaccines.

「Nielsen BookData」 より

詳細情報

• NII書誌ID(NCID): BA50558508
• ISBN:
  • 0824776658
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: New York
• ページ数/冊数: xv, 584 p.
• 大きさ: 29 cm