Principles of molecular rheumatology

Author(s)

• Tsokos, George C.

Bibliographic Information

Principles of molecular rheumatology

edited by George C. Tsokos

（Current molecular medicine / series editor J. Larry Jameson）

Humana Press, c2000

Description and Table of Contents

Description

George Tsokos and a panel of authoritative clinicians and researchers synthesize the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology. These established experts describe the biochemical mechanisms by which apoptosis, cell signaling, complement, lipids, and viruses contribute to disease expression, and detail both immune and nonimmune cell function in rheumatic diseases. Their review of the major rheumatic diseases integrates the cellular, biochemical, and molecular biological mechanisms that are important in rheumatic disease pathogenesis. Path-breaking and illuminating, Principles of Molecular Rheumatology expands the envelope of clinical understanding to reveal the biological roots underlying rheumatologic disease, as well as the nature and roles of the powerful new therapeutics now emerging for its optimal treatment.

Table of Contents

Part I. Molecular Mechanisms in Rheumatic Diseases Genetics Peter K. Gregersen Viruses Andras Perl Apoptosis John D. Mountz, Hui-Chen Hsu, Huang-Ge Zhang, and Tong Zhou Humoral Response Gary S. Gilkeson T-Cell Signaling Gary A. Koretzky and Erik J. Peterson Adhesion and Costimulatory Molecules Vassiliki A. Boussiotis, Gordon J. Freeman, and Lee M. Nadler Transcription Factors Henry K. Wong Immune Complexes Mark H. Wener Complement V. Michael Holers Eicosanoids and Other Bioactive Lipids Leslie J. Crofford Collagens Sergio A. Jimenez Part II. Cellular Mechanisms in Rheumatic Diseases T-Lymphocytes Nilamadhab Mishra and Gary M. Kammer B-Lymphocytes Robert F. Ashman Monocytes and Macrophages James M. K. Chan and Sharon M. Wahl Polymorphonuclear Cells Michael H. Pillinger, Pamela B. Rosenthal, and Bruce N. Cronstein Synoviocytes David E. Yocum Chondrocytes Tariq M. Haqqi, Donald D. Anthony, and Charles J. Malemud Osteoblasts and Osteoclasts Stavros C. Manolagas Animal Models Thomas J. Lang and Charles S. Via Part III. Pathogenesis of Rheumatic Diseases Systemic Lupus Erythematosus Stamatis-Nick C. Liossis and George C. Tsokos Rheumatoid Arthritis Richard M. Pope and Harris Perlman Inflammatory Myopathies Norbert Goebels and Reinhard Hohlfeld Systemic Sclerosis Timothy M. Wright Vasculitis Joerg J. Goronzy and Cornelia M. Weyand Osteoarthritis Robin Poole and Ginette Webb Osteoporosis Stavros C. Manolagas Heritable Disorders of Connective Tissue Petros Tsipouras Part IV. Molecular Aspects of Treatment of RheumaticDiseases Corticosteroids Henry K. Wong and George C. Tsokos Cytotoxic Drugs David A. Fox and W. Joseph McCune Complement Inhibitors Savvas C. Makrides Cytokine Response Modifiers Richard E. Jones and Larry W. Moreland Restoration of Immune Tolerance Woodruff Emlen Metalloproteases and Their Modulation as Treatment in Osteoarthritis Johanne Martel-Pelletier, Ginette Tardif, Julio Fernandes, and Jean-Pierre Pelletier Gene Therapy Robert P. Kimberly

by "Nielsen BookData"

Details

• NCID: BA5121510X
• ISBN:
  • 0896037738
• LCCN: 00024930
• Country Code: us
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: Totowa, N.J.
• Pages/Volumes: xiii, 542 p.
• Size: 26 cm
• Classification:
  • DC21 : 616.7/23/07
• Subject Headings:
  • LCSH : Rheumatism--Molecular aspects
  • LCSH : Arthritis--Molecular aspects
  • LCSH : Rheumatism--Pathophyssiology
  • LCSH : Arthritis--Pathophysiology
• Parent Bibliography ID:
  • BA5121529X