The fetal and neonatal pulmonary circulations
Author(s)
Bibliographic Information
The fetal and neonatal pulmonary circulations
(American Heart Association monograph series)
Futura Pub., c2000
Available at 4 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes bibliographical references and index
Description and Table of Contents
Description
Birth is a sudden, traumatic transition of environments. Once the placental oxygen supply ceases, the foetus has only minutes to establish pulmonary oxygen transport, which requires not only inflation of the lungs, but also sudden and sustained changes in the lung circulation. Not long ago, research in this field was largely restricted to morphology and physiology. Now the powerful new tools of cellular and molecular biology have begun to
shed light on the physiological processes in the developing lung and its supporting vasculature. In 22 chapters, three main sections explore lung growth and development, vascular cell growth and differentiation, and the mechanisms of hemodynamic control in the neonate; extensive illustrations give a comprehensive picture of pulmonary circulatory development. Factors controlling vasculogenesis and angiogenesis are described by the scientists who pioneered the field. Similarly, the intracellular signaling cascades that determine proliferation or growth inhibition of fibroblasts, smooth muscle cells, and endothelial cells are also presented in an understandable manner. Finally, the role of
substances, such as nitric oxide and endothelin, that control the hemodynamics of the fetal and neonatal circulations are discussed in detail, particularly in relation to the changes occurring at birth.
This book will inform basic scientists as well as the clinician and student, and should be of particular interest to pediatric cardiologists, pulmonary medicine physicians, and vascular biologists.
Table of Contents
Preface. (E.K. Weir, S.L. Archer, J.T. Reeves).
Section I. Lung Growth and Development.
1. The Development of Concepts of the Ontogeny of the Pulmonary Circulation.
(A.M. Rudolph).
2. The de Novo Formation of Blood Vessels in the Early Embryo and in the Developing Lung. (C.J. Drake, C.D. Little).
3. Early Development of the Vascular System of the Mouse Lung: Ontogeny of Endothelial Cell Heterogeneity. (R. Auerbach, O. Mierzoeva, K.C. Meyer).
4. Structural Elements of Human Fetal and Neonatal Lung Vascular Development. (D.E. deMello).
Section II. Vascular Cell Growth and Differentiation.
5. Contribution of the Adventitial Fibroblast to Pulmonary Vascular Disease.
(K.R. Stenmark, M. Das, D. Bouchey, E.C. Dempsey).
6. The Role of Thrombospondins 1 and 2 in Vascular Development.
(L.C. Armstrong, T.R. Kyriakides, P. Bornstein).
7. Elastic Fiber Proteins in Pulmonary Vascular Development.
(J.M.W. Hausladen, R.P. Mecham).
8. Proteolytic Modulation of the Extracellular Matrix. (M. Rabinovitch).
9. Signal Transduction Kinases in the Regulation of Matrix Metalloproteinase-9 Expression in Vascular Smooth Muscle Cells. (A. Cho, M.A. Reidy).
10. Transcription Factors Controlling Cellular Proliferation During Vascular Repair. (R.C. Smith, T. Mano, K. Walsh).
11. Perlecan Heparan Sulfates in the Control of Vascular Smooth Muscle Cell Proliferation. (M.C.M. Weiser-Evans, K.R. Stenmark).
12. B-Myb Represses Collagen Gene Expression in Bovine Vascular Smooth Muscle Cells. (K.E. Kypreos, D.J. Marhamati, M.A. Nugent, G.E. Sonenshein).
13. Mechanical Forces in Vascular Growth and Development. (B.L. Langille).
Section III. Mechanisms of Hemodynamic Control in the Neonate.
14. Lung Arteriolar Endothelial Cell Proliferation at Birth: Possible Roles of Stretch and Hypoxia. (J.T. Reeves).
15. Physiologic Roles of Nitric Oxide in the Perinatal Pulmonary Circulation.
(S.H. Abman, J.P. Kinsella, T.A. Parker, L. Storme, T.D. Le Cras).
16. Regulation of Endothelial Nitric Oxide Synthase Expression in the Developing Lung. (P.W. Shaul).
17. The Role of Endothelin in Perinatal Pulmonary Vasoregulation.
(D.D. Ivy, S.H. Abman).
18. O2-Sensitive K+ Channel Activity in the Ovine Pulmonary Circulation Shifts with Maturation. (D.N. Cornfield, H.L. Reeve, E.K. Weir).
19. Regulation of Ion Channels in the Ductus Arteriosus. (H.L. Reeve, E.K. Weir).
20. Cytochrome P450 in the Contractile Tone of the Ductus Arteriosus: Regulatory and Effector Mechanisms. (F. Coceani).
21. Maturational Changes in the Human Pulmonary Vascular Resistance.
(J.C. Huhta, J. Rasanen).
22. The Pulmonary Vasculature in Congenital Diaphragmatic Hernia.
(R. Tibboel, S.M.K. Shehata, A.H. Guldemeester).
Index.
by "Nielsen BookData"