Rheumatoid arthritis : frontiers in pathogenesis and treatment
著者
書誌事項
Rheumatoid arthritis : frontiers in pathogenesis and treatment
Oxford University Press, 2000
- : hbk
- タイトル別名
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Rheumatoid arthritis : new frontiers in pathogenesis and treatment
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The old saying "we now know all about rheumatoid arthritis except what causes it and how to cure it" may still be true, but we certainly have a number of clues. This book presents the cutting edge of developments in etiology, mechanisms of inflammation, disease manifestations and management of this common, crippling disease. Therapy for RA has traditionally been with non-steroid anti-inflammatory drugs, progressing to second-line drugs, but this has not been effective in preventing erosion of bone and symptoms. Rapid advances in knowledge have led to new concepts in the mechanisms of the disease and new possibilities for treatment. This book deals with the This book is intended for clinical specialist and research rheumatologists. Immunologists working in areas of research in rheumatology.
目次
- SECTION ONE: ETIOLOGY
- 1. Current Perspectives on the genetics of rheumatoid arthritis
- 2. Epidemiology of rheumatoid arthritis
- 3. Infection in the pathogenesis of rheumatoid arthritis
- 4. Experimental Models for rheumatoid arthritis
- SECTION TWO: MECHANISMS OF INFLAMMATION
- 5. Examination of the synovium and synovial fluid
- 6. The Role of macrophages in rheumatoid arthritis
- 7. The Role of T lymphocytes in rheumatoid arthritis
- 8. The role of neutrophils in rheumatoid arthritis
- 9. The role of fibroblast-like synoviocytein rheumatoid arthritis
- 10. Adhesion, migration and cell trafficking
- 11. Cytokine networks
- 12. Apoptosis in rheumatoid arthritis: Cause or Consequence
- 13. Rheumatoid Factor
- 14. Mehanisms of joint destruction
- 15. Pain mechanisms in rheumatoid arthritis
- SECTION THREE: CLINICAL ASPECTS
- 16. Rheumatoid arthritis: clinical picture and its variants
- 17. Extra-articular features of rheumatoid arthritis
- 18. The neuroendocrine axis in rheumatoid arthritis
- 19. Imaging
- 20. Outcome and mortality
- 21. Molecular markers for assessment of cartilage damage in rheumatoid arthritis
- SECTION FOUR: DRUG THERAPY
- 22. NSAIDs and analgesics
- 23. Systemic glucocorticoids in rheumatoid arthritis
- 24. Methotrexate
- 25. Gold, antimalarials, sulphasalazine and other DMARDs
- 26. Intra-articular therapy
- 27. Combination therapy for rheumatoid arthritis
- SECTION FIVE: NON-DRUG THERAPY
- 28. The Impact of physiotherapy
- 29. Occupational therapy and assistive technology
- 30. Diets
- 31. Psychological and social aspects
- 32. Patient education
- 33. Non-drug management of chronic pain
- 34. Health economics
- SECTION SIX: SURGICAL THERAPY
- 35. Large joints and feet
- 36. The hand
- 37. The cervical spine
- 38. Medical synovectomy (synoviorthesis)
- SECTION SEVEN: FRONTIERS OF THERAPY
- 39. Anticytokine therapy: TNF Inhibitors and other novel approaches
- 40. The design of clinical trials
- 41. Anti-T lymphocyte therapies
- 42. Antimacrophage therapies
- 43. Inhibition of matrix metalloproteinases in rheumatoid arthritis
- 44. Small molecule inhibitors of signal transduction
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