Combinatorial chemistry and technology : principles, methods, and applications
著者
書誌事項
Combinatorial chemistry and technology : principles, methods, and applications
Marcel Dekker, c1999
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
"Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular ""libraries."" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules."
目次
- Combinatorial chemistry and combinatorial technologies - principles and applications
- synthesis and characterization of peptide libraries
- solid-phase synthesis of organic libraries
- resins, linkers, and reactions for solid-phase synthesis of organic libraries
- solution-phase combinatorial libraries of small organic molecules
- direct deconvolution techniques for pool libraries of small organic molecules
- encoding techniques for pool libraries of small organic molecules
- analytical characterization of synthetic organic libraries
- automation in combinatorial chemistry
- key ingredients for efficient high-throughput screening
- computational aspects of combinatorial chemistry
- biological libraries
- peptide display libraries - design and construction
- making and selecting from phage antibody libraries
- biopanning
- globular oligonucleotide screening via the SELEX process -aptamers as high-affinity, high-specificity compounds for drug development and proteomic diagnostics
- economics of combinatorial chemistry and combinatorial technologies.
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