Cardiac gap junctions : physiology, regulation, pathophysiology, and pharmacology
著者
書誌事項
Cardiac gap junctions : physiology, regulation, pathophysiology, and pharmacology
Karger, c1998
大学図書館所蔵 件 / 全3件
-
該当する所蔵館はありません
- すべての絞り込み条件を解除する
注記
Includes bibliographical references (p. 121-139) and index
内容説明・目次
内容説明
The most important communication mechanism between cardiac cells is electrical transmission via low resistance pathways, the so-called gap junction channels. This book provides a comprehensive overview of what is known about cardiac gap junctions. An introduction into the various aspects of activation propagation and coupling in the heart is followed by a detailed description of the structure and diversity of gap junctions, including amino acid sequences and species variability. Subsequent chapters discuss their distribution, physiology and functions and the regulation of expression. The author then goes on to put these basic findings into a clinical context - the changes of gap junction distribution in the course of cardiac disease and their implications. A further chapter presents pharmacological approaches to the modulation of gap junction channel conductivity and outlines possible therapeutic strategies. The final part of the book describes the methods of investigation including double cell voltage clamp, immunohistochemistry, isolation procedures for gap junctions and dye coupling assays.
目次
- Introduction - cellular coupling, cardiac activation patterns and arrhythmia
- structure and diversity of gap junction channels
- distribution of gap junctions in the heart
- function and physiology of gap junction channels
- regulation of gap junction expression, synthesis and assembly
- gap junction in cardiac disease
- pharmacology interventions at gap junctions
- methods for investigation of gap junctions.
「Nielsen BookData」 より