Genetic aberrancies and neurodegenerative disorders
著者
書誌事項
Genetic aberrancies and neurodegenerative disorders
(Advances in cell aging and gerontology, v. 3)
JAI Press, c1999
大学図書館所蔵 全1件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliograhicl references and index
内容説明・目次
内容説明
The brain is the most complex organ system in the human, both in the intricacy of its cellular architecture and in the extent of its repertoire of macromolecules. The Aging Brain presents the current state of understanding of molecular, cellular, and functional changes that occur in normal brain aging, and compares and contrasts those changes with events occurring in age-related neurodegenerative disorders. The chapters, written by world leaders in the field of brain aging, provide a timely and comprehensive consideration of key areas of this rapidly growing field of aging research. The topics covered include structural, functional, biochemical and molecular changes that occur during usual aging and in age-related neurological disorders. An emphasis is placed on emerging findings at the cellular and molecular levels. The roles of oxidative stress and perturbed energy metabolism in aging and neurodegenrative disorders are covered in considerable detail. In addition, the impact of aging and disease on specific neurotransmitter, neurotrophic factor and cytokine signaling pathways is reviewed. Finally, recent findings concerning possible approaches to reduce risk for age-related neurodegenerative disorders, such as caloric restriction, are presented. The collective body of information presented in The Aging Brain will provide those stepping into the field of brain aging with an overview of our current understanding of fundamental changes that occur in the aging brain, and their molecular and cellular underpinnings. At the same time, the book delves deeply into critical mechanistic details of brain aging that should prove valuable to experts in the field.
目次
Contents. List of Contributors. Preface (M.P. Mattson and J.W. Geddes). Toward a Cognitive Neuroscience of Normal Aging (P.R. Rapp and M. Gallagher). The Neuronal Cytoskeleton: Changes Associated with Age, Neurodegenerative Disease, and Neuronal Insult (J.W. Geddes and A.I. Matus). Structural Changes in the Aged Brain (D.W. Dickson). Cerebrovascular Changes in the Aging Brain (J.C. de la Torre). Metabolism of the Aging Brain (J.P. Blass, G.E. Gibson, and S. Hoyer). Contribution of Mitochondrial Alterations to Brain Aging (G. Benzi and A. Moretti). Protein Oxidation Processes in Aging Brain (D.A. Butterfield and E.R. Stadtman). Neuroendocrine Aspects of the Aging Brain (P.M. Wise, J.P. Herman, and P.W. Landfield). Changes in Neurotransmitter Signal Transduction Pathways in the Aging Brain (J.F. Kelly and G.S. Roth). Food Restriction and Brain Aging (C.E. Finch and T.E. Morgan). Neurotrophic Factors and the Aging Brain (M.P. Mattson and O. Lindvall). Index.
「Nielsen BookData」 より