Regulation of gene expression
著者
書誌事項
Regulation of gene expression
（Essays in biochemistry, v. 37）
Portland, 2001
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注記
Includes bibliographical references and index
Series editor: S.J. Higgins
内容説明・目次
内容説明
A guide through the cellular processes which govern gene expression, starting with transcription initiation and highlighting universal principles. The essays provide insights into present work and concepts which are elucidating the mechanisms that lead to protein synthesis in the correct cell at the precise time and in response to appropriate signals. Epigenetic mechanisms are described by which information about the regulatory state of a gene is transmitted to a cells descendants. Aspects of gene regulation by extracellular and intracellular signalling pathways are discussed, as well as post-transcriptional control of gene expression. Also illustrated in the book is the crucial importance in normal development and growth of the coupling of gene expression to cell cycle progression - where dysregulation can lead to cell death or innapropriate proliferation.
目次
- Transcription initiation - imposing specificity by localization, M. Ptashne and A. Gann
- activation and repression of transcription initiation in bacteria, G. Lloyd et al
- regulation of the initiation of eukaryotic transcription, G. Gill
- transcriptional regulation in the context of chromatin structure, A.P. Wolffe
- DNA methylation and control of gene expression in vertebrate development, R.R. Meehan and I. Stancheva
- signalling from the cell surface to the nucleus, M. Lee and S. Goodbourne
- control of gene expression and the cell cycle, H.M. Chan et al
- regulation of mRNA translation
- to live or die - a cell's choice, C.G. Proud
- future perspectives, N. Hastie.
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