Biology of renal tubulo-interstitial cells
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Bibliographic Information
Biology of renal tubulo-interstitial cells
（Experimental nephrology, 7 /5-6 /99）
S. Karger, 1999
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"Journal of renal cell biology"--Cover
Includes bibliographies and indexes
Description and Table of Contents
Description
For the last ten years, there has been an exponential increase in the number of scientific reports on methodological and mechanistic aspects of renal tubular cell culture. This publication provides an update on the state of the art, presenting various areas of research. Starting off with current methodological aspects in renal primary cell practice, the focus then shifts to the complex issue of interstitial cells of the kidney, presenting the different techniques for the isolation of the fibroblasts and their identification in cultures by morphological criteria. Further chapters relate to topics such as the flow-sorting of cells, targeted oncogenesis in transgenic mice, advances and possible drawbacks of cultured cells in the elucidation of phenotypic changes induced by transgenesis, the role of the proximal tubular cell as mediator of interstitial inflammation and tissue injury/fibrosis, as well as the association of glucose-induced accumulation of type IV collagen and fibronectin with alterations in the degradative pathways of these matrix components. Primary cultures of human renal cells are well suited for future studies on the therapeutic efficacy of gene therapy, decorin, growth factor receptor antagonist and somatostatin analogues, greatly enhancing our understanding of the molecular mechanisms, and ultimately, treatment of progressive tubulo-interstitial disease. Nephrologists, pharmacologists and physiologists interested in cell culture will find this publication of great value.
Table of Contents
- Introduction - biology of renal tubulo-interstitial cells, M.E. De Broe and M.F. Helbert
- tissue culture of human renal epithelial cells using a defined serum-free growth formulation, D.A. Sens, C.J. Detrisac et al
- isolation, culture and characterization of human renal proximal tubule and collecting duct cells, A.L. Trifillis
- flow cytometric immunodissection of the human nephron in vivo and in vitro, M.J.F. Herbert, S. Dauwe and M.E. De Broe
- renal interstitial fibroblast culture, C. Grupp and G.A. Muller
- immortalized kidney cells derived from transgenic mice harbouring L-type pyruvate kinase and vimentin promoters, A. Vandewalle
- modulation of cell differentiation in perfusion culture, W.W. Minuth, P. Steiner et al
- renal tubular cells cultured from genetically modified animals, G. Friedlander, I. Runembert et al
- antisense and kidney cell research, M.B. Ganz
- protein overload activates proximal tubular cells to release vasoactive and inflammatory mediators, C. Zoja, A. Benigni and G. Remuzzi
- tubular epithelial cells - a critical cell type in the regulation of renal inflammatory processes, C. Van Kooten, M.R. Daha and L.A. van Es
- cytokine-stimulated nitric oxide production in the human renal proximal tubule and its modulation by natriuretic peptides - a novel immunomodulatory mechanism? P.K. Chatterjee, G.M. Hawksworth and J.S. MacLay
- decreased degradation of collagen and fibronectin following exposure of proximal cells to glucose, A.O. Phillips, K. Morrisey et al
- hypoxia-induced changes in extracellular matrix metabolism in renal cells, J.T. Norman, C. Orphanides et al
- fibrogenic effects of cyclosporin A on the tubulointerstitium - role of cytokines and growth factors, D.W. Johnson, H.J. Saunders et al.
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