Solid-phase synthesis : a practical guide
著者
書誌事項
Solid-phase synthesis : a practical guide
Marcel Dekker, c2000
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules.
目次
- The solid support strategy in solid-phase synthesis
- amino acids -alpha-amino protecting groups
- side-chain protecting groups
- solid supports for the synthesis of peptides and small molecules
- coupling methods - solid-phase formation of amide and ester bonds
- homodetic cyclic peptides
- disulfide formation in synthetic peptides and proteins -the state of the art
- solid-phase convergent approaches to the synthesis of native peptides and proteins
- preparation of glyco-, phospho-, and sulfopeptides
- oligonucleotide synthesis
- synthesis of oligonucleotide-peptide conjugates and nucleopeptides
- the chemistry of peptide nucleic acids
- solid-phase synthesis of pseudopeptides and oligomeric peptide backbone mimetics
- instrumentation
- the purification of synthetic peptides
- analysis of synthetic peptides
- the chromatographic analysis of combinational arrays - parallel HPLC and HPLC-MS.
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