Tumor angiogenesis and microcirculation

Author(s)

• Voest, Emile E.
• D'Amore, Patricia A.

Bibliographic Information

Tumor angiogenesis and microcirculation

edited by Emile E. Voest, Patricia A. D'Amore

（Basic and clinical oncology, 24）

Marcel Dekker, c2001

Note

Includes bibliographical references and index

Description and Table of Contents

Description

Compiling the latest developments in anticancer therapies based on the connection between tumor and capillary growth, Tumor Angiogenesis and Microcirculation presents a comprehensive overview of diverse aspects of angiogenesis-related cancer research. Highlights the role angiogenesis and its inhibitors play in the growth, metastasis, and dormancy of tumors! Facilitating the progress of clinical practice with insights from methodological and scientific results, Tumor Angiogenesis and Microcirculation summarizes biological principles of angiogenesis and microcirculation, from endothelial cells and pericytes, and extracellular matrix regulation to matrix metalloproteinases (MMPs) and plasmin and plasmin inhibitors examines proangiogenic factors such as vascular endothelial (VEGF) and basic fibroblast (bFGF) growth factors, tie receptors, and cytokines outlines methods for discovering angiogenesis stimulators and inhibitor peptides, particularly the clinical development of thrombospondin, angiostatin, endostatin, and MMP inhibitors reveals the link between oncogenes and neoplastic angiogenesis and its regulation by the organ microenvironment investigates tumor vascularity in relation to tumor growth and the spread of cancer details promising future applications, including perspectives in vascular cancer therapy and more! Combining the resources of 60 recognized experts and nearly 3000 pertinent literature references, drawings, photographs, and x-rays, Tumor Angiogenesis and Microcirculation profits oncologists, pathologists, hematologists, and radiation and hemato-oncologists; surgeons and internists; cardiologists; immunologists; cell, molecular, and developmental biologists; rheumatologists; ophthalmologists; dermatologists; and medical school students in these disciplines.

Table of Contents

Biological Principles of Angiogenesis Endothelial Cells and Pericytes in Tumor Vasculature Diane C. Darland and Patricia A. D'Amore The Extracellular Matrix and the Regulation of Angiogenesis Joseph A. Madri Matrix Metalloproteinases (Matrixins) and Their Inhibitors (TIMPS) in Angiogenesis Teresa A. Bennett and William G. Stetler-Stevenson Regulation of Cell Migration in the Process of Angiogenesis Bela Anand-Apte and Bruce R. Zetter Plasmin, Plasmin Inhibitors, and Angiogenesis Martijn F. B. G. Gebbink Assays to Study Angiogenesis Assays to Study Angiogenesis Robert Auerbach and Wanda Auerbach Screening for Angiogenesis Inhibitors with the Chick Chorioallantoic Membrane and the Mouse Corneal Micropocket Assays Robert J. D'Amato Capillary Morphogenesis In Vitro: Cytokine Interactions and Balanced Proteolysis Roberto Montesano and Michael S. Pepper Skin Fold Chamber Models Michael Leunig and Konrad Messmer Protease Assays and Their Use in the Discovery of Novel Regulators of Angiogenesis Li Yan, Inmin Wu, and Marsha A. Moses Angiogenic Factors Vascular Endothelial Growth Factor/Vascular Permeability Factor: Multiple Biological Activities for Promoting Angiogenesis Donald R. Senger Tie Receptors, Ang Ligands Yuji Gunji, Arja Kaipainen, Kristiina Iljin, Eola Kukk-Valdre, Berndt Enholm, and Kari Alitalo Vascular Endothelial Growth Factor Receptors Arja Kaipainen, Eija Korpelainen, and Kari Alitalo Regulation of Vascular Endothelial Growth Factor (VEGF) Expression Ilan Stein and Eli Keshet Fibroblast Growth Factors David A. Moscatelli and Daniel B. Rifkin Role of Proangiogenic Cytokines and Inhibitors of Neovascularization in Tumor Angiogenesis Peter J. Polverini and Robert M. Strieter Regulation of Angiogenesis The Link Between Oncogenes, Signal Transduction Therapy, and Tumor Angiogenesis Robert S. Kerbel, Alicia Viloria-Petit, Futoshi Okada, and Janusz Rak Genetic Control of Angiogenesis by Tumor Suppressor Genes Maartje Los and Emile E. Voest Regulation of Neoplastic Angiogenesis by the Organ Microenvironment Rakesh Kumar and Isaiah J. Fidler Role of Macrophages in Tumor Angiogenesis Peter J. Polverini Phenotypic Analysis of Endothelium from the Tumor Vasculature Gerard Groenewegen and Arjan W. Griffioen Angiogenesis Inhibitors: Preclinical and Clinical Drugs Drug Delivery and Angiogenesis Inhibition in the Treatment of Brain Tumors Laurence D. Rhines, Matthew G. Ewend, and Henry Brem Matrix-Associated Endogenous Inhibitors of Angiogenesis Raghu Kalluri and Vikas P. Sukhatme vss? and Its Antagonists in the Control of Angiogenesis Brian P. Eliceiri and David A. Cheresh The Role of Vascular Endothelial Growth Factor in Angiogenesis Napoleone Ferrara TNP-470: Preclinical and Clinical Development Deborah M. Milkowski and Rachelle A. Weiss Matrix Metalloproteinase Inhibitors Peter D. Brown Tumoral Vascularity: What Does It Tell Us About the Growth and Spread of Cancer? Noel Weidner The Prognostic and Diagnostic Value of Circulating Angiogenic Factors in Cancer Patients Olaf A. J. Kerckhaert and Emile E. Voest Future Perspectives Perspectives in Vascular Cancer Therapy: An Introduction Geert H. Blijham The Combination of Antiangiogenic Therapy with Cytotoxic Therapy: A Systems Approach Beverly A. Teicher Targeting the Vasculature of Solid Tumors Philip E. Thorpe and Sophia Ran Combining Antivascular Approaches with Radiotherapy: A Perspective Juliana Denekamp Antiangiogenic Gene Therapy Jaap C. Reijneveld and Emile E. Voest

by "Nielsen BookData"

Details

• NCID: BA52839858
• ISBN:
  • 0824702646
• Country Code: us
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: New York
• Pages/Volumes: xvi, 623 p.
• Size: 24 cm
• Parent Bibliography ID:
  • BA19832545