Proceedings of the 4th International Stem Cell Workshop : high-dose therapy and transplantation of haematopoietic stem cells (Bad Saarow/Berlin, Germany, April 29th-May 1st, 1999)
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書誌事項
Proceedings of the 4th International Stem Cell Workshop : high-dose therapy and transplantation of haematopoietic stem cells (Bad Saarow/Berlin, Germany, April 29th-May 1st, 1999)
Blackwell Wissenschafts-Verlag, 2000
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Includes bibliographical references and index
内容説明・目次
内容説明
High-dose therapy with allogeneic or autologous stem cell transplantation as well as additional supportive measures have brought important advances in the therapy of malignant diseases. Allogeneic and especially autologous peripheral blood stem cell grafting as opposed to allogeneic bone marrow transplantation is a subject of intensive research. Comprising a a series of scientific papers presented at the 4th International Stem Cell Workshop, High-Dose Therapy and Transplantation of Haematopoietic Stem Cells summarizes the most recent findings in this field, both in basic and clinical research, including newly developed methods. In this context, emphasis has been placed on: * Acute and chronic myeloid and lymphocytic leukaemia * Multiple myeloma * Myelodysplastic syndromes * Aplastic anaemia and autoimmune disease * Certain solid tumours (carcinomas of the breast, the ovary, the bronchia, the germ cell and soft tissue sarcoma) Novel approaches, such as metakine transplantation and gene therapy, are outlined from a theoretical as well as a practical point of view.
The crucial question of early and late complications in allogeneic transplantation for solid tumours is dealt with expert contributions. A special section is dedicated to cord blood transplantation. Finally attention is drawn to further topics such as cell culture methods or the identification and separation of growth factors in haematopoietic stem cell cultures. With its international team of contributors, this new book presents the state-of-the-art in the field of high-dose therapy of malignant and non-malignant diseases.
目次
- Part 1: Haematological Malignancies - Stem Cell Transplantation for Chronic Lymphocytic Leukaemia. An Updated Review
- Fludarabine-Based Low Toxicity Conditioning for Allogeneic Peripheral Blood Stem Cell Transplantation
- Tandem Autologous Transplantation for Multiple Myeloma: First Results of a German Multicentre Study
- Therapeutic Strategies in Primary AL Amyloidosis. Part 2: Solid Tumours - High Dose Chemotherapy in Metastatic Breast Cancer
- Disseminated Tumour Cells in Breast Cancer Patients Undergoing High-Dose Therapy
- Large-Volume Leukapheresis in Small Children
- High-Dose Therapy in Soft Tissue Sarcomas
- Prospective, Randomised Comparison of Tandem High-Dose Chemotherapy versus Dose-Intensified Conventional Chemotherapy in Breast Cancer - 2nd Interim Analysis of the Westdeutsche Study Group (WSG)
- Apheresis on Day 4 Versus Day 5 after Stimulation with G-CSF Alone in Breast Cancer Patients: Influence on CD34+ Cell Yield, Subpopulation and Tumour-Cell Contamination. Part 3: Miscellaneous - High-Dose Immunosuppressive Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation with CD34+ Selected Cells for Patients with Systemic Sclerosis
- Early Injections after Autologous and Allogeneic Stem Cell Transplantation
- Culturing Human Umbilical Cord Blood
- Storage of Cord Blood for Related or Unrelated Use
- Infectious Complications after High-Dose Therapy with Autologous Peripheral Blood Stem Cell Transplantation
- rhG-CSF Mobilisation and Collection of Peripheral Blood Progenitor Cells in 71 Healthy Donors
- Determination of Cytokeratin-Expressing Cells in Blood, Bone Marrow and Blood Progenitor Cell Products
- Generation of a Combination Vaccine for Stimulation of an Anti-Leukaemic Response. Part 4: Experimental Transplantation - Prospects for Intensified Consolidation Chemotherapy by Genetic Chemoprotection of Haematopoietic Cells
- Retroviral Gene Transfer into Haematopoietic Cells on a Clinically Relevant Scale
- Adhesion Molecules as Targets for Novel Therapeutic Approaches Using Antisense Oligonucleotides
- Haematopoietic Progenitor Cell Mobilisation and Homing is Controlled at the Level of Bone Marrow Endothelium by Adhesion Molecules and Chemokines
- Reduction of Nitrosourea-Induced Haematotoxicity by Over-expression of O6 -Methylguanine DNA Methyltransferase
- Asymmetric Division and Self-Renewal of Haematopoietic Stem Cells. Part 5: Novel Approaches in Clinical Transplantation - Adoptive Immunotherapy with CD4+ Donor Lymphocyte Transfusion after Allogeneic Haematopoietic Stem Cell Transplantation
- Non-Myeloablative Haematopoietic Stem Cell Transplants
- Allogeneic Stem Cell Transplantation Using Non-Myeloablative Transplant Regimens. Index.
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