An introduction to medicinal chemistry
著者
書誌事項
An introduction to medicinal chemistry
Oxford University Press, 2001
2nd ed
- : pbk
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内容説明・目次
内容説明
This lively, highly illustrated text provides undergraduate and postgraduate students with an accessible introduction to medicinal chemistry. It covers basic principles and background, and then describes the general tactics and strategies involved in developing an effective drug. Through the use of numerous examples it highlights both the difficulties faced by the medicinal chemist and the great potential of rational drug design. The second edition has five new chapters and is updated to include recent advances in the field. It is updated throughout with the latest descoveries. There are five new chapters covering: the molecular structure of receptors and the mechanisms of signal transduction; combinatorial synthesis; the role of computers in drug design; adrenergics; and drug discovery and drug development.
目次
- GENERAL PRINCIPLES
- 1. Drugs and the medicinal chemist
- 2. The why and the wherefore
- 3. Protein structure
- 4. Drug action at enzymes
- 5. Drug action at receptors
- 6. Receptor
- 7. Nucleic acids
- 8. Drug discovery and drug development
- 9. Drug design - drug/target interactions
- 10. Pharmacokinetics
- 11. Quantitative structure-activity relationships (QSAR)
- 12. Combinatorial synthesis
- 13. Computers in medicinal chemistry
- TOPICS
- 14. Antibacterial agents
- 15. The peripheral nervous system-cholinergics, anticholinergics, and anticholinesterases
- 16. The adrenergic nervous system
- 17. The opium analgesics
- 18. Cimetidine - a rational approach to drug design
- APPENDICES
- GLOSSARY
- FURTHER READING
- INDEX
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