Type-2 diabetic nephropathy in Japan : from bench to bedside
Author(s)
Bibliographic Information
Type-2 diabetic nephropathy in Japan : from bench to bedside
(Contributions to nephrology, v. 134)
Karger, c2001
- Other Title
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Type-two diabetic nephropathy in Japan : from bench to bedside
Available at 1 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes bibliographical references and indexes
Description and Table of Contents
Description
Type-2 diabetic nephropathy is one of the major long-term microvascular complications occurring in nearly 40% of diabetic patients in Japan. The purpose of this book is to review recent work on the genetic background, pathogenesis and treatment of this disorder and to provide the most up-to-date findings on these subjects in Japan. The pathogenesis of diabetic nephropathy includes both metabolic and / or hemodynamic factors, as well as renal hypertrophy. Hyperglycemia is necessary, but not sufficient, for its initiation and progression: The toxicity of persistent hyperglycemia results from glucose overutilization and multiple secondary effects. Moreover, diabetic nephropathy is generally considered to alter the chemical composition of the glomerular basement membrane and mesangium. At present, it is supposed that the increases in extracellular matrix accumulation due to TGF-beta activation might be related to the glomerular sclerosis in diabetic nephropathy. Although large numbers of candidate genes have been analyzed, those related to initiation and progression are still obscure in patients with type-2 diabetic nephropathy. Presenting clinical findings and issues related to laboratory analysis, this book will be of interest for nephrologists, diabetologists, pathologists, biochemists, general physicians and residents.
Table of Contents
- Basic findings: genetic background - patients, Makita, Y., Tomino, Y.
- animal models, Shike, T., Funabiki, K., Tomino, Y.
- mesangial cell dysfunction as a pathogenesis of diabetic nephropathy, Haneda, M., Koya, D., Kikkawa, R.
- advanced glycation end products and the pathogenesis of diabetic nephropathy, Yamagishi, S., Takeuchi, M., Makita, Z.
- carbonyl stress, Suzuki, D., Miyata, T., Kurokawa, K.
- role of macrophages in the pathogenesis of diabetic nephropathy, Shikata, K., Makino, H.
- lipid abnormality, Mune, M., Otani, H., Kimura, K.
- impairment of ECM production, Horikoshi, S., Kanamaru, Y., Funabiki, K., Tomino, Y.
- podocyte loss and progression of diabetic nephropathy, Shirato, I., Hishiki, T., Tomino, Y.
- efficacy of ACE inhibitor (captopril) on glomerular antioxidant enzyme activity and hypertension in diabetic hypertensive rats, Shou, I., Fukui, M., Tomino, Y.. Clinical findings and treatment: classification of Type-2 diabetic nephropathy in Japan, Tomino, Y.
- serum cystatin C, Tomino, Y.
- urinary type-IV collagen, Tomino, Y.
- urinary albumin fragments, Yagame, M., Sakai, H.
- renal biopsy findings and clinical course, Nishi, S., Ueno, M., Gejyo, F.
- blood glucose control, Uchino, H., Kawamori, R.
- blood pressure control in diabetic nephropathy, Katayama, S.
- dietary protein restriction and nutritional adequacy in diabetic nephropathy, Kanauchi, M.
- future strategy - gene therapy for diabetic nephropathy, Isaka, Y., Imai, E.. Summary: Tomino, Y.
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