Glutamate and gaba receptors and transporters : structure,function and pharmacology
著者
書誌事項
Glutamate and gaba receptors and transporters : structure,function and pharmacology
（THE TAYLOR & FRANCIS SERIES IN PHARMACEUTICAL SCIENCECES）
Taylor & Francis, 2002
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The ubiquitous presence of glutamate and GABA receptors in the nervous system makes these receptor systems pivotal to our understanding of neurotransmission. Cloning of the molecular components of these receptor systems has provided insights to the selectivity of many drugs and detailed characterisation at the molecular level is emerging. Moreover, continuous development of novel and selective drugs has revealed detailed information on the mechanism of receptor activation and regulation. However, the rapid development of different aspects of glutamate and GABA receptor research makes it increasingly difficult to establish a general view of the field. Studies of the receptors are a multi-disciplinary task employing many specialised techniques. This book conveys recent discoveries in a framework of the basic concepts in the field of glutamate and GABA receptor research. Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology is suitable for postgraduate students studying ligand gated channels but also beneficial for industrial and academic research scientists in both the glutamate and GABA field. Universities offering programs in neuroscience, molecular pharmacology or medicinal chemistry will find this a valuable reference.
目次
Ionotropic Glutamate Receptors: Functional and Pharmacological Properties in Relation to Constituent Subunits. Molecular Structure of Ionotropic Glutamate Receptors. Glutamate Receptor Trafficking. Pharmacology of NMDA Receptors. Pharmacology of AMPA/kainate Receptors. Metabotropic Glutamate Receptors (mGluRs): Structure and Functions. Pharmacology of Metabotropic Receptors. Insights into GABAA Receptor Complexity From the Study of Cerebellar Granule Cells: Synaptic and Extrasynaptic Receptors. GABAA Receptor Complex: Structure and Function. GABAA Receptor Complex: Structural Requirements for Ligand Interactions. Molecular Structure of the GABAB Receptors. Phamacology of GABAB Receptors. Structure, Function and Regulation of Glutamate Transporters. GABA Transporters: Functional and Pharmacological Properties. Transgenic Models for Glutamate Receptor Function. Transgenic Models for GABAA Receptor Function. Glutamatergic transmission: Therapeutic Prospects for Schizophrenia and Alzheimer's Disease. GABA-ergic Transmission: Therapeutic Prospects.
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