Neurotransmitter receptors in actions of antipsychotic medications
著者
書誌事項
Neurotransmitter receptors in actions of antipsychotic medications
（Pharmacology & toxicology）
CRC Press, c2000
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Years of extensive investigation into neurophysiology, neurochemistry, and behavioral pharmacology have produced an understanding of antipsychotic medication action that is much more refined than the original dopamine hypothesis. New perspectives offer an array of novel drugs - drugs that pose a lower risk of developing tardive dyskinesia, have fewer extrapyramidal side effects, are less sedating, and attempt to address the negative symptoms of schizophrenia. Neurotransmitter Receptors in Actions of Antipsychotic Medications presents a glimpse into the development of these breakthroughs and the field's current status in one definitive volume.
The exhaustive chapters cover the basic knowledge of schizophrenic syndromes and provide a general description of available antipsychotic drugs. Leading specialists recount the investigation into a variety of receptors in drug action and present unique topics like endogenous receptor occupation by antipsychotic drugs and regulation of brain receptors. The book also includes a survey of the future perspectives in drug design.
Each year, pharmaceutical companies invest billions of dollars in developing hundreds of medications to treat psychiatric disorders. Neurotransmitter Receptors in Actions of Antipsychotic Medications helps you study and appreciate the dynamics of these medications. You will understand the effects on receptors; predict the action, adverse side effects, and drug-drug interactions; and improve the modern antipsychotic medications that already enable people coping with schizophrenia to work, have meaningful social relationships, and live more productive lives.
目次
Schizophrenic Syndromes. General Overview of Antipsychotic Medications. Effects of Antipsychotic Drugs on Dopamine Release and Metabolism in the Central Nervous System. Antipsychotic Drugs, Dopamine D2, and Schizophrenia. D1 Dopamine Receptors, Schizophrenia, and Antipsychotic Medications. Serotonin Receptors as Targets of Antipsychotic Medications. Role of Adrenergic Receptors in Effects of Antipsychotic Medications on Prefrontal Cortical Function. Glutamate Receptors in Schizophrenia and Antipsychotic Drugs. Antipsychotic Effects of Sigma Drugs. GABA-ergic Drugs in Schizophrenia. Receptor Occupancy by Antipsychotics - Concepts and Findings. Regulation of Neurotransmitter Receptors by Antipsychotic Medications. Modulation of Cellular Signaling Pathways by Antipsychotic Medications. The Role of Neurotransmitter Receptors in the Adverse Effects of Antipsychotic Drugs. Future Perspectives of Antipsychotic Drug Development.
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