Molecular epidemiology : a practical approach
著者
書誌事項
Molecular epidemiology : a practical approach
(The practical approach series, 251)
Oxford University Press, c2001
- Hbk
- Pbk
大学図書館所蔵 全13件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
- 巻冊次
-
Pbk ISBN 9780199638109
内容説明
The 'molecular' aspect of molecular epidemiology refers to the application of molecular biological approaches to epidemiologic problems. The variety and power of molecular methods are rapidly expanding our capability to dissect etiologic mechanisms of disease. The 'epidemiologic' aspect, meanwhile, refers to utilizing the tools and perspectives of epidemiology to comprehend observations in molecular biology. An increasingly sophisticated variety of molecular
techniques are being applied to generate an explosion of data on exposures and outcomes whose significance must be determined.
The wealth of information generated by the Human Genome Project and the corresponding efforts in microbial genomics are providing researchers with extraordinary new opportunities to further understand the etiology of disease. Molecular epidemiology is rapidly evolving through the application of more relevant markers of exposure and better identification of subgroups at increased risk of early disease processes and progression.
This volume provides a broad overview of the diverse approaches encompassed by this emerging discipline. Chapters 1-3 highlight concepts and methods at the forefront of studies of infectious diseases, and include a synopsis of general epidemiologic design and analysis, as well as current techniques for molecular typing of microbial pathogens. Chapters 4-6 are focussed on recent advances in studying host genetics, including methods for the detection of mutations and polymorphisms,
identification of linkage among alleles of genes on a given chromosome, and the use of DNA pooling to increase efficiency in association studies of genetically complex traits. Chapters 7 and 8 deal with the relationship between pathologies and immune system genetics, and on the use of DNA sequence information to
garner insights into the evolution of infectious pathogens, and into the evolution and function of the immune system.
目次
- Introduction
- 1. Epidemiological methods for studies of genetic factors that influence infectious diseases
- 2. Molecular Differentiation of bacterial strains
- 3. Detection and quantification of heterogeneous viral targets: using HIV as a model
- 4. Mutation Detection by Single-Stranded Conformation Polymorphism and Denaturing High Performance Liquid Chromatography
- 5. DNA Pooling Methods for association mapping of complex disease loci
- 6. Single-sperm typing: a rapid alternative to family based linkage analysis
- 7. PCR-based methods of HLA typing
- 8. Evolutionary Analysis of Molecular Sequence Data
- 巻冊次
-
Hbk ISBN 9780199638116
内容説明
The 'molecular' aspect of molecular epidemiology refers to the application of molecular biological approaches to epidemiologic problems. The variety and power of molecular methods are rapidly expanding our capability to dissect etiologic mechanisms of disease. The 'epidemiologic' aspect, meanwhile, refers to utilizing the tools and perspectives of epidemiology to comprehend observations in molecular biology. An increasingly sophisticated variety of molecular
techniques are being applied to generate an explosion of data on exposures and outcomes whose significance must be determined.
The wealth of information generated by the Human Genome Project and the corresponding efforts in microbial genomics are providing researchers with extraordinary new opportunities to further understand the etiology of disease. Molecular epidemiology is rapidly evolving through the application of more relevant markers of exposure and better identification of subgroups at increased risk of early disease processes and progression.
This volume provides a broad overview of the diverse approaches encompassed by this emerging discipline. Chapters 1-3 highlight concepts and methods at the forefront of studies of infectious diseases, and include a synopsis of general epidemiologic design and analysis, as well as current techniques for molecular typing of microbial pathogens. Chapters 4-6 are focussed on recent advances in studying host genetics, including methods for the detection of mutations and polymorphisms,
identification of linkage among alleles of genes on a given chromosome, and the use of DNA pooling to increase efficiency in association studies of genetically complex traits. Chapters 7 and 8 deal with the relationship between pathologies and immune system genetics, and on the use of DNA sequence information to
garner insights into the evolution of infectious pathogens, and into the evolution and function of the immune system.
目次
- Introduction
- 1. Epidemiological methods for studies of genetic factors that influence infectious diseases
- 2. Molecular Differentiation of bacterial strains
- 3. Detection and quantification of heterogeneous viral targets: using HIV as a model
- 4. Mutation Detection by Single-Stranded Conformation Polymorphism and Denaturing High Performance Liquid Chromatography
- 5. DNA Pooling Methods for association mapping of complex disease loci
- 6. Single-sperm typing: a rapid alternative to family based linkage analysis
- 7. PCR-based methods of HLA typing
- 8. Evolutionary Analysis of Molecular Sequence Data
「Nielsen BookData」 より